Relafen (Nabumentone) clinical pharmacology: Rx List: "After oral administration, approximately 80% of a radiolabelled dose of nabumetone is found in the urine, indicating that nabumetone is well absorbed from the gastrointestinal tract. Nabumetone itself is not detected in the plasma because, after absorption, it undergoes rapid biotransformation to the principal active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA). Approximately 35% of a 1000 mg oral dose of nabumetone is converted to 6MNA and 50% is converted into unidentified metabolites which are subsequently excreted in the urine. Following oral administration of nabumetone, 6MNA exhibits pharmacokinetic characteristics that generally follow a one-compartment model with first order input and first order elimination."
http://www.rxlist.com/cgi/generic/nabume.htm

Side effects to consider while taking Relafen (Nabumetone): Natural Essentials: "More common side effects may include: Abdominal pain, constipation, diarrhea, dizziness, fluid retention, gas, headache, itching, nausea, rash, ringing in ears Less common side effects may include: Dry mouth, fatigue, inability to fall or stay asleep, increased sweating, inflammation of the mouth, inflammation of the stomach, nervousness, sleepiness, vomiting Rare side effects may include: Agitation, anxiety, confusion, dark, tarry, bloody stools, depression, difficult or labored breathing, difficulty swallowing, fluid retention, general feeling of illness, hives, increase or loss of appetite, large blisters, pins and needles, pneumonia or lung inflammation, sensitivity to light, severe allergic reactions, skin peeling, stomach and intestinal inflammation and/or bleeding, tremor, ulcers, vaginal bleeding, vertigo, vision changes, weakness, weight gain, yellow eyes and skin"
http://www.naturalessentials.com/relafen.htm

Drug information data for Relafen (Nabumetone): Health Square: "Stomach and intestinal ulcers can occur without warning. Remember to get regular check-ups. Make sure the doctor knows if you have kidney or liver disease. Relafen should be used with caution. This drug can cause fluid retention and swelling. It should be used with caution if you have congestive heart failure or high blood pressure. Relafen can cause increased sensitivity to sunlight. Possible food and drug interactions when taking this medication If Relafen is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Relafen with blood-thinning drugs such as Coumadin and aspirin. Other drugs with which Relafen could possibly interact include: Diuretics (HydroDIURIL, Lasix) Lithium (Lithonate) Methotrexate"
http://www.healthsquare.com/pdrfg/pd/monos/relafen.html

Health professional version information for Relafen (Nabumetone): University of Iowa Nursing: "Indications: Acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatiod arthritis, and other inflammatory conditions. May be used as an analgesic and an antipyretic. Onset: From 30 minutes to several hours or longer Peak Plasma Concentrations: 2.5-4 hours, plasma protein binding 90+% Steady State: After repeated doses once a day for 5 days, steady state is reached after the 5th dose at once daily dosing Metabolism: Nabumetone is metabolized in the liver to active metabolite, and excreted by the kidney Half-Life: 22-30 hours, Half lfie is about 24 hours on the average."
http://coninfo.nursing.uiowa.edu/sites/pedspain/NSAIDS/Relafet.htm

Relafen (Nubumetone) Overdose: Pharm Med: "Since only one case of nabumetone overdose has been reported, the experience is limited. If acute overdose occurs, it is recommended that the stomach be emptied by vomiting or lavage and general supportive measures be instituted, as necessary. In addition, the use of activated charcoal, up to 60 grams, may effectively reduce nabumetone absorption. Coadministration of nabumetone with charcoal to man has resulted in an 80% decrease in maximum plasma concentrations of the active metabolite.The one overdose occurred in a 17-year-old female patient who had a history of abdominal pain and was hospitalized for increased abdominal pain following ingestion of 30 nabumetone tablets (15 grams total). Stools were negative for occult blood and there was no fall in serum hemoglobin concentration. The patient had no other symptoms. She was given an H2-receptor antagonist and discharged from the hospital without sequelae."
http://www.vinet.com/~pharmmed/nabume.htm#sect-Overdosage

Relafen (Nubumetone) Contraindications and drug interactions: Arthritis Insight: "Contraindications: Those who have had a prior allergic reaction to other NSAIDs should not take Nabumetone. Nabumetone should be avoided in those with a history of peptic ulcer or GI bleeding. Use during the third trimester of pregnancy is not recommended. Nabumetone is not recommended for use in nursing mothers. Drug Interactions: Nabumetone can increase the effect of anti-coagulants.Nabumetone should not be taken with any other NSAIDs.Because of the potent nature of this medicine, be sure to tell your doctor about any other medicines you are taking, including nonprescription medicines and vitamins"
http://arthritisinsight.com/medical/meds/relafen.html

Relafen (Nubumetone) side effects questions and answers: Excite drugs and health: "Question: For the past few years, I have experienced muscle/joint pain in my left hip during the spring and fall. My doctor has prescribed Relafen twice a day to relieve this. Within a day or two, I have begun to experience bouts of allergic, histamine reations such as tearing, runny nose, severe mucas drainage and uncontrollable coughing which have lasted up to several hours at a time. This is accompanied by wheezing and often, ear aches. Typically, I end up with a sinus infection and have to take antibiotics. This pattern has been with me for 3 years now. I have been diagnosed as being allergic to my environment.Today, I looked up Relafen on the internet and was suprised to find that patients with allergic type reactions such as asthma should not take this medication. Is it possible that I am allergic to Relafen and, that, for what ever reason I have the muscle/joint pain, when I take it I start this cycle? I have told my current physician of the coincidence, he doesn't think they are related, but doesn't discount the possibility. Eventually the symptoms dissapear and I return to my normal activities with no obvious side effects. What would trigger the muscle/joint pain in the spring and fall? I have had xrays and have no joint obvious joint disease. If you have any suggestions or opinions, please advise me. Thank you. Answer: The reaction you are referring to is an increase in asthma with these class of drugs in susceptible individuals. Aspirin would have the same effect. The tearing and other allergy symptoms would not be expected to be caused by Relafen. Have you seen a Rheumatologist? Been tested for connective tissue diseases? If not, I would."
http://www.druginfonet.com/faq/faqrelaf.htm

Relafen (Nubumetone) general information: Nurses PDR: "Classification: Nonsteroidal anti-inflammatory agent See Also: See also Nonsteroidal Anti-Inflammatory Drugs .Action/Kinetics: Time to peak plasma levels: 2.5-4 hr. t1/2 of active metabolite: 22.5-30 hr.Uses: Acute and chronic treatment of osteoarthritis and rheumatoid arthritis. Has also been used to treat mild to moderate pain including postextraction dental pain, postsurgical episiotomy pain, and soft tissue athletic injuries.Contraindications: Lactation.Special Concerns:Safety and efficacy have not been determined in children."
http://www.nursespdr.com/members/database/ndrhtml/nabumetone.html

Relafen (Nubumetone) Special studies: Health and Age: "Gastrointestinal: Relafen (nabumetone) was compared to aspirin in inducing gastrointestinal blood loss. Food intake was not monitored. Studies utilizing 51 Cr-tagged red blood cells in healthy males showed no difference in fecal blood loss after 3 or 4 weeks' administration of Relafen 1000 mg or 2000 mg daily when compared to either placebo-treated or nontreated subjects. In contrast, aspirin 3600 mg daily produced an increase in fecal blood loss when compared to the Relafen -treated, placebo-treated or nontreated subjects. The clinical relevance of the data is unknown. The following endoscopy trials entered patients who had been previously treated with NSAIDs. These patients had varying baseline scores and different courses of treatment. The trials were not designed to correlate symptoms and endoscopy scores. The clinical relevance of these endoscopy trials, i.e., either G.I. symptoms or serious G.I. events, is not known. Ten endoscopy studies were conducted in 488 patients who had baseline and post-treatment endoscopy. In 5 clinical trials that compared a total of 194 patients on Relafen 1000 mg daily or naproxen 250 mg or 500 mg twice daily for 3 to 12 weeks, Relafen treatment resulted in fewer patients with endoscopically detected lesions less than 3mm
http://www.healthandage.com/html/res/pdr/html/76763060.htm

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