Lodine (Etodolac) pharmacology: Rx List: "Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of etodolac, like that of other NSAIDs, is not known, but is believed to be associated with the inhibition of prostaglandin biosynthesis.Pharmacokinetics The activity of Lodine XL is due to the parent drug, etodolac. The free fraction is less than 1% and is independent of concentration over the therapeutic range. Etodolac is not dialyzable. Etodolac is extensively metabolized in the liver, with renal elimination of its metabolites. The terminal half-life ranges between 7.3 and 8.3 hours. Less than 1% of the dose is excreted unchanged in urine.Absorptions Lodine and Lodine XL both contain etodolac, but differ in their release characteristics. The systemic availability of etodolac from Lodine XL is generally greater than 80%. After administration of 400 mg of Lodine XL, a Cmax of 8.6 µg/mL was observed 3 to 12 hours post dose. Peak concentrations are dose proportional for both total and free etodolac following Lodine doses up to 400 mg every 12 hours, but following a 600 mg dose, the peak is about 20% higher than predicted on the basis of lower doses. After oral administration of Lodine XL in doses of 800 mg once daily, peak concentrations are dose proportional for both total and free etodolac whereas peak concentrations following 1200 mg Lodine XL once daily were about 20% lower than that predicted by lower doses. Table 1 shows the comparison of pharmacokinetic parameters for etodolac and Lodine XL."
http://www.rxlist.com/cgi/generic/etodolac_cp.htm

Less and more common side effects of Lodine (Etodolac): Natural Essentials: "More common side effects may include: Abdominal pain, black stools, blurred vision, chills, constipation, depression, diarrhea, dizziness, fever, gas, increased frequency of urination, indigestion, itching, nausea, nervousness, rash, ringing in ears, painful or difficult urination, vomiting, weaknessLess common side effects may include:Abdominal bleeding, abnormal intolerance of light, anemia, asthma, blood disorders, congestive heart failure, dry mouth, fainting, flushing, hepatitis and other liver problems, high blood pressure, high blood sugar in some diabetics, hives, inability to sleep, inflamed blood vessels, inflammation of mouth or upper intestine, kidney problems, including kidney failure, loss of appetite, peptic ulcer, rapid heartbeat, rash, severe allergic reactions, skin disorders including increased pigmentation, sleepiness, Stevens-Johnson syndrome (peeling skin), sweating, swelling (fluid retention), thirst, visual disturbances, yellowed skin and eyes"
http://www.naturalessentials.com/lodine.htm

Pharmacokinetic Summary of Lodine (Etodolac): Sunnybrook and Woman's College Health Sciences Centre's: "In clinical trials, most adverse reactions observed were mild and transient. Fluid retention and edema have been observed as has gastrointestinal discomfort. In patients treated for three to six months the incidence of upper GI ulcers, gross bleeding or perforation is approximately 1% and this increases to 2-4% after one year of treatment[4]. The recommended dose of etodolac for acute pain is 200 to 400 mg every 6 to 8 hours, as needed, not to exceed a total daily dose of 1200 mg[4].Etodolac is a pyranocarboxylic acid non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic activities. Etodolac is more than 99% bound to plasma proteins. The free fraction is less than 1% and is independent of etodolac total concentration. Less than 1% of etodolac is excreted unchanged in the urine[1]."
http://www.icomm.ca/shsc/kinetics/etodolac.html

Clinical information about Lodine (Etodolac): Doctor's Guide: "Clinical trials have established that Lodine XL is effective in managing the pain and inflammation associated with osteoarthritis and rheumatoid arthritis. In one study of Lodine XL used for the treatment of rheumatoid arthritis (RA), 500 mg of Lodine XL taken as two tablets once daily was found to be effective in relieving the symptoms of RA, especially morning stiffness -- which is significant because it indicates that Lodine XL 500 mg was working to relieve inflammation throughout the night. This is an important benefit of Lodine XL -- it can relieve arthritis symptoms around the clock"
http://www.pslgroup.com/dg/58112.htm

Special warnings about Lodine (Etodolac): Health Square: "Peptic ulcers and bleeding can occur without warning. You may have other problems with bleeding as well. Call your doctor if you have any signs or symptoms of stomach or intestinal ulcers or bleeding, blurred vision or other eye problems, skin rash, weight gain, or fluid retention and swelling. This drug should be used with caution if you have kidney or liver disease; and it can cause liver inflammation in some people. Do not take aspirin or any other anti-inflammatory medications while taking Lodine, unless your doctor tells you to do so. If you are taking Lodine over an extended period of time, your doctor should check your blood for anemia. This drug can increase water retention. Use with caution if you have heart disease or high blood pressure."
http://www.healthsquare.com/newrx/LOD1232.HTM

Cautions and drug interactions for People using Lodine (Etodolac): Virtual Drug Store: "Because Etodolac, Ultradol or Lodine causes stomach irritation, people with sensitive stomachs or a history of ulcer disease should not use it. A cross sensitivity among non steroidal anti inflammatory drugs exists, thus people who are sensitive or even allergic to one member of this groups of drugs will have the same problems with Etodolac, Ultradol or Lodine. Long term use of Etodolac, Ultradol or Lodine can lead to kidney damage and people with existing kidney problem should use Etodolac, Ultradol or Lodine with care. Etodolac, Ultradol or Lodine is able to reduce protein binding of the blood thinner, warfarin. Because Etodolac, Ultradol or Lodine can affect the functioning of both the liver and kidney, it can alter levels of various drugs in the body - digoxin, beta blockers like propranolol, lithium, methotrexate. A dosage adjustment may be required."
http://www.virtualdrugstore.com/pain/etodolac.html

Use of and dosage of Lodine (Etodolac): University of Michigan: "Lodine (LOE-deen) is a nonaddictive prescription medicine widely used as a pain reliever for arthritis (arth-RITE-is). It is also used to treat joint pain, stiffness, swelling and gout (GOWT). It works by reducing tissue concentration of inflammatory and painful hormones. As a result, the pain is relieved, although it may take four to 24 hours to notice the effects. Lodine is usually prescribed in tablet, liquid, or capsule form. Follow your doctor's dosage recommendations to the letter and if you miss a dose, do not double the dosage to compensate, just take the next regular dose as scheduled. Some side effects of Lodine may include muscle cramps, abdominal pain, black stools or mouth ulcers. If you experience any of these or other adverse symptoms, call your doctor. If your symptoms are severe, or if you overdose, seek emergency treatment at once."
http://www.med.umich.edu/1libr/prescrpt/inflam02.htm

Clinical Trials: Studies in pain relief of Lodine (Etodolac) comprehensive drug info included: Wyeth Info: "Controlled clinical trials in analgesia were single-dose, randomized,double-blind,parallel studies in three pain models, including dental extractions. The analgesic effective dose for Lodine established in these acute pain models was 200 to 400 mg. The onset of analgesia occurred approximately 30 minutes after oral administration. Lodine 200 mg provided efficacy comparable to that obtained with aspirin (650 mg). Lodine 400 mg provided efficacycomparable to that obtained with acetaminophen with codeine (600 mg + 60 mg). The peak analgesic effect was between 1 to 2 hours. Duration of relief averaged 4 to 5 hours for 200 mg of Lodine and 5 to 6 hours for 400 mg of Lodine as mea-sured by when approximately half of the patients required remedication."
http://www.wyethinfo.com/etodolac.htm

Etodolac (Etogesic Rx) a pain reliever for dogs with arthritis: Vet Info: "Etodolac (Etogesic Rx) is a non-steroidal anti-inflammatory (NSAID) medication. It is a relatively new medication and it is considered to be less likely to upset the gastrointestinal tract than older NSAIDs, such as aspirin. This medication can be used long term but it is recommended to use the lowest dose that will work to control the pain when long term use is necessary. A similar medication, carprofen (Rimadyl Rx) has been associated with liver problems in a small number of dogs and it is possible that this effect could surface for etodolac, as well. If there are any signs of decreased appetite, loss of appetite, lethargy or anything that concerns you while your dog is on this medication it would be best to discontinue it and call your vet as soon as symptoms are noted."
http://www.vetinfo.com/detogesic.html

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