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Darvocet (Propoxyphene Napsylate): Mosby's GenRx: "Darvocet is an opioid analgesic used to treat mild to moderate pain…The CNS-depressant effect of propoxyphene is additive with that of other CNS depressants, including alcohol. Because of the potent nature of this medicine, be sure to tell your doctor about any other medicines you are taking, including nonprescription medicines and vitamins."
http://jraworld.arthritisinsight.com/medical/meds/darvocet.html

Darvocet (Propoxyphene Napsylate): PDR® Family Guide To Prescription Drugs®: "The propoxyphene in these drugs slows down the central nervous system and intensifies the effects of alcohol. Heavy use of alcohol with this drug may cause overdose symptoms. If these medications are taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining them with the following: Antiseizure medications such as Tegretol, Antidepressant drugs such as Elavil, Antihistamines such as Benadryl Muscle relaxants such as Flexeril, Narcotic pain relievers such as Darvocet, Sleep aids such as Halcion, Tranquilizers such as Xanax and Valium, Warfarin-like drugs such as Coumadin. The use of these drugs with propoxyphene can lead to potentially fatal overdose symptoms."
http://www.healthsquare.com/pdrfg/pd/monos/darvocet.htm

Side Effects of Darvocet (Propoxyphene Napsylate): Harvard Medical School Consumer Health Information: "You should see your doctor regularly for tests and examinations if you take this medication for a prolonged period. Prolonged use can cause nerve damage as well as physical dependence. Adverse reactions may be more likely and more severe in older patients. Propoxyphene has not caused birth defects in animals. Human studies have not been done. Before you use this medication, tell your doctor if you are pregnant or plan to become pregnant. Overuse of the medication during pregnancy can cause physical dependence in the newborn."
http://www.intelihealth.com/IH/ihtIH?d=dmtSimple&c=214240&p=~br,AOL|~st,8124|~r,WSAOL002|~b,*|

Considerations and contraindications of Darvocet N-100 (Propoxyphene Napsylate): AgeNet, Inc: "Caution is advised for use in the elderly since they are more susceptible to the depressant effects on the central nervous system (i.e. confusion, sedation, dizziness). Also, people with compromised kidney or liver function must use extreme caution since small doses of Darvocet N-100 could have increased effect/toxicity."http://agenet.agenet.com/?Url=link.asp?DOC/1311

Darvocet (Propoxyphene Napsylate); Action: MedicineNet Inc: "It works by affecting the brain's perception of pain. Propoxyphene is often combined with TYLENOL as in DARVOCET-N, or with ASPIRIN as in DARVON COMPOUND- 65 to achieve more effective pain relief. Since propoxyphene is often combined with TYLENOL or ASPIRIN, patients should be aware of the precautions and side effects related to the other two medications. SIDE EFFECTS: The most frequent side effects include dizziness, sedation, nausea, and vomiting. Other side effects include constipation, abdominal pain, rash, headache, and hallucinations."
http://www.medicinenet.com/Script/Main/Art.asp?li=MNI&ArticleKey=732

"Drug Challenge" Brief Article concerning Darvocet (Propoxyphene Napsylate) and other narcotics: Marcy Portnoff Gever: "You routinely administer combination drugs ... but do you know what's in them? To find out, match each combination of ingredients in Section II with its correct name in Section I." (Example) "propoxyphene napsylate, 100 mg; acetaminophen, 650 mg…A practitioner may prescribe this combination to relieve mild to moderate pain. Propoxyphene napsylate is a centrally acting opioid analgesic; acetaminophen is a nonopioid analgesic. Warn your patient that he may feel drowsy or dizzy while taking this combination. Tell him to avoid other medications that contain analgesics."
http://www.findarticles.com/m3231/1_30/58916393/p1/article.jhtml/

Nursing considerations for Darvocet (Propoxyphene Napsylate): Prescription RX: "Children Breathing problems may be especially likely to occur when narcotic analgesics are given to children younger than 2 years of age. These children are usually more sensitive than adults to the effects of narcotic analgesics. Acetaminophen, codeine, and propoxyphene pass into the breast milk. It is not known whether other narcotic analgesics pass into the breast milk. However, these medicines have not been reported to cause problems in nursing babies.."
http://www.pdqrx.com/Darvacet.htm

Absorption and metabolism of Darvocet (Propoxyphene Napsylate): Traumatic Brain Injury Resource Guide: "Peak plasma concentrations are reached in 2-2 1/2 hours. Metabolism: Metabolized in the liver by microsomal enzymes. Half-life: 6-12 hours. The CNS-depressant effect of propoxyphene is additive with that of other CNS depressants, including alcohol. Propoxyphene may slow the metabolism of a concomitantly administered drug."
http://www.neuroskills.com/index.html?main=tbi/pain.html

Darvocet (Propoxyphene Napsylate) dosage indications: Delmar, A division of learning: "Nonnarcotic analgesic: Acetaminophen, 325 (Darvocet-N 50) or 650 mg (Darvocet-N 100). Analgesic: Propoxyphene napsylate, 50 or 100 mg. Tablets Analgesia. Two Darvocet-N 50 tablets or 1 Darvocet-N 100 tablet q 4 hr, not to exceed 600 mg/day of propoxyphene napsylate. Reduce total daily dose in impaired hepatic or renal function."
http://www.nursespdr.com/members/database/ndrhtml/darvocetn50anddarvocetn100.html

Toxicity and overdose with Darvocet (Propoxyphene Napsylate): Mosby Inc: "Propoxyphene products in excessive doses, either along or in combination with other CNS depressants, including alcohol, are a major cause of drug-related deaths. Fatalities within the first hour of over dosage are not uncommon. In a survey of deaths due to over dosage conducted in 1975, in approximately 20% of the fatal cases, death occurred within the first hours (5% occurred within 15 minutes)."
http://www.rxlist.com/cgi/generic/propox_wcp.htm