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Amevive.com:"AMEVIVE is the first biologic treatment approved for adults with moderate to severe chronic plaque psoriasis. The first biologic to go to the root of the problem. The first biologic that can provide those who respond months of relief after treatment has stopped. Clinically proven effective, even in many severe cases."
http://www.amevive.com
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Amevive, Clinical Results, Centerwatch.com:"Amevive was evaluated in two randomized, double blind, placebo-controlled studies in 726 adult subjects with chronic plaque psoriasis. In both trials, Amevive or placebo was administered once a week for 12 weeks. In total 77% of subjects had previously received systemic therapy and/or phototherapy for psoriasis.
Response to treatment in both studies was defined as the proportion of subjects with a reduction in score on the Psoriasis Area and Severity Index (PASI)³ of at least 75% from baseline at two weeks following the 12-week treatment period. Other treatment responses included the proportion of subjects who achieved a scoring of 'almost clear' or 'clear' by Physician Global Assessment (PGA) and the proportion of subjects with a reduction in PASI of at least 50% from baseline two weeks after the 12-week treatment period."
http://www.centerwatch.com/patient/drugs/dru820.html
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Amevive, How does it work? Drugdigest.org:"How Amevive exactly works is not clearly understood. Psoriasis is a disease in which the immune system plays a key role and Amevive is thought to modify the immune response that causes psoriasis. Specifically, Amevive may block specific system cells known to trigger inflammation in the skin. This inflammation is responsible for the development of psoriasis."
http://www.drugdigest.org/DD/DVH/MOA/0,8635,552042|Amevive,00.html
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Amevive, What is the most important information I should know about alefacept? Drugs.com:"Alefacept reduces levels of certain white blood cells in the body. If the level of these white blood cells falls too low, treatment with alefacept may need to be withheld temporarily or discontinued. Your doctor will monitor your white blood cell levels during treatment.
• Alefacept may increase the risk of developing cancer. Do not take alefacept without first talking to your doctor if you have cancer or a history of cancer.
• Alefacept reduces certain actions of the immune system and may increase the risk of developing an infection. Contact your doctor immediately if you develop symptoms of an infection such as fever or chills, sore throat, coughing, or burning with urination."
http://www.drugs.com/xq/cfm/pageid_0/htm_d04843A1.htm/type_mtm/tgid_27/bn_Amevive/qx/index.htm
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Amevive, Important Information about Amevive, Laurushealth.com:"Plaque psoriasis is the most common form of psoriasis, a chronic relapsing disease of the skin that is characterized by scaling and inflammation. According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases, psoriasis affects between 1 and 2 percent of the United States population, or as many as 5.5 million people. Psoriasis primarily affects adults. People with psoriasis may suffer discomfort, including pain and itching, restricted motion in their joints, and emotional distress.
Amevive treats plaque psoriasis through a unique immunosuppressive mechanism of action. Specifically, Amevive is believed to work by simultaneously blocking and reducing the cellular component of the immune system that is thought to play a significant role in the disease process."
http://www.laurushealth.com/Library/FDADrugApprovals/Amevive.htm
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Alefacept, Amevive, Drug Class & Mechanism, Medicinenet:"Alefacept is an injectable drug that suppresses the immune system and is used for the treatment of psoriasis. Scientists believe that psoriasis is caused by an increase in the production of one type of immune cell, T-lymphocytes, in response to the attachment of a stimulant (antigen) to the lymphocyte. The stimulated T-lymphocytes cause skin cells to grow rapidly, and the rapid growth of the skin cells produces the skin plaques of psoriasis. Alefacept reduces the stimulation and production of T-lymphocytes by attaching to the site on the T-lymphocytes where the antigen attaches. This prevents the antigen from binding and activating the T-lymphocytes. Alefacept also decreases the life-span of T-lymphocytes that already have been produced by increasing the activity of another type of immune cell, natural killer cells, that kill T-lymphocytes. Alefacept was approved by the FDA in January, 2003."
http://www.medicinenet.com/alefacept/article.htm
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Amevive, Who should avoid Amevive? psoriasis.org:"The FDA classified Amevive as a category B treatment, meaning pregnant women should take Amevive only if clearly needed.
Women who are nursing should consult with their physician about whether to discontinue the drug, based on the mothers' severity of psoriasis.
Elderly patients should exercise caution with Amevive; it is not clearly known whether Amevive will affect them differently than younger patients.
Children should not take Amevive; the safety and efficacy of Amevive has not been studied in this group.
People with infections or low T cell counts."
http://www.psoriasis.org/research/biologics/amevive.php
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Amevive, Side Effects, Rxlist.com:"Commonly observed adverse events seen in the first course of placebo-controlled clinical trials with at least a 2% higher incidence in the AMEVIVE®-treated patients compared to placebo-treated patients were: pharyngitis, dizziness, increased cough, nausea, pruritus, myalgia, chills, injection site pain, injection site inflammation, and accidental injury. The only adverse event that occurred at a 5% or higher incidence among AMEVIVE®-treated patients compared to placebo-treated patients was chills (1% placebo vs. 6% AMEVIVE®), which occurred predominantly with intravenous administration."
http://www.rxlist.com/cgi/generic3/amevive_ad.htm
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Canadian Pharmacies, Get a Free Quote on Amevive, Alefacept, Psoriasis, Skincare, Prescription Drugs, Medications, Medicines:"Online Pharmacies in Canada will save you up to 90% on your prescription drugs. Thanks to Canadian prescription drugs price control and Government's prohibition on direct-to-consumer advertising, we can fill your prescriptions at discount prices. Now you can save 40% to 90% on U.S. FDA approved brand names and generic prescription drugs through our network of licensed affiliated Canadian pharmacies and have them mailed directly to your home ... without sacrificing safety, quality and service. We can fill prescriptions written by American Doctors, after review by our Canadian Doctors to issue a Canadian prescription. You must have previously been on the drugs being requested for at least 30 days and have had a physical examination in the last twelve (12) months to have a prescription filled."
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