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Quetiapine Fumarate(Seroquel), Consumer Information, Seroquel.com:"SEROQUEL® (quetiapine fumarate) tablets (pronounced SER-O-KWELL), is an oral medication for the treatment of schizophrenia in adults.
It is a member of a category of medicines called "atypical antipsychotics." SEROQUEL has been found to be effective in treating symptoms, while causing few of the unpleasant side effects of older medications."
http://www.seroquel.com/cons_asp/index.asp
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Quetiapine Fumarate(Seroquel), What are the Uses, Health-Center,com:" Seroquel, quetiapine fumarate, was approved by the FDA on September 29, 1997 and is used to treat:
Schizophrenia.
In general, this medication has less severe motor side effects (such as akathisia and tremor) than standard antipsychotic medications. Seroquel also seems to be effective in the treatment of both positive and negative symptoms of schizophrenia."
http://www2.health-center.com/pharmacy/antipsychotics/atypical_medic/seroquel.htm
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Quetiapine Fumarate(Seroquel), What does Seroquel treat, National Alliance for the Mentally Ill:"
Findings from extensive clinical trials have shown Seroquel to be effective in the treatment of both positive (e.g., delusions, thought disorder, and hallucinations) and negative (e.g., social withdrawal, lack of energy, apathy, and reduced ability to express emotion) symptoms of schizophrenia. Seroquel affects a broad range of neurotransmitter receptors, including serotonin receptors. In comparative clinical trials, Seroquel has been shown to be as effective as standard antipsychotic agents, such as chlorpromazine (Thorazine) and haloperidol (Haldol)."
http://www.nami.org/helpline/seroquel.html
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Quetiapine Fumarate(Seroquel), Seroquel (Quetiapine Fumarate) Reduces Psychosis In Chronic Schizophrenia, Parkinson's Patients, September 14, 2000, Doctor's Guide:"Scientists presented evidence from two new clinical studies that suggest treatment with the atypical antipsychotic Seroquel® (quetiapine fumarate) Tablets significantly improved cognitive function in some patients with chronic schizophrenia or Parkinson's disease who experience symptoms of psychosis."
http://www.pslgroup.com/dg/1e12b6.htm
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Quetiapine Fumarate(Seroquel), About Seroquel, Psychiatry In Practice:"Seroquel (quetiapine) is manufactured by AstraZeneca and is currently approved in over 70 markets. Seroquel combines broad-based efficacy in the treatment of positive, negative, cognitive and affective symptoms of schizophrenia, while offering excellent tolerability. Seroquel is associated with an incidence of EPS and prolactin elevation no different to placebo across the full dosage range, a neutral effect on weight in long-term treatment, and no clinically important effects on QT interval. To date, over 850,000 people have been treated with Seroquel world-wide."
http://www.psychiatry-in-practice.com/html/aboutseroquel/about.asp
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Quetiapine Fumarate(Seroquel), Why is this drug prescribed, PDR.net:"Seroquel combats the symptoms of schizophrenia, a mental disorder marked by delusions, hallucinations, disrupted thinking, and loss of contact with reality. It is the first in a new class of antipsychotic medications. Researchers believe that it works by diminishing the action of dopamine and serotonin, two of the brain's chief chemical messengers."
http://www.gettingwell.com/drug_info/rxdrugprofiles/drugs/SER1402.shtml
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Quetiapine Fumarate(Seroquel), Indications, RXlist:"SEROQUEL is indicated for the management of the manifestations of psychotic disorders.
The antipsychotic efficacy of SEROQUEL was established in short-term (6-week) controlled trials of schizophrenic inpatients (See CLINICAL PHARMACOLOGY).
The effectiveness of SEROQUEL in long-term use, that is, for more than 6 weeks, has not been systematically evaluated in controlled trials. Therefore, the physician who elects to use SEROQUEL for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient ."
http://www.rxlist.com/cgi/generic2/quetiap_ids.htm
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Quetiapine Fumarate(Seroquel), Range and Frequency, Whole Health MD:"Initial dose is 25 mg twice a day. On the second and third days, the dose should be increased by 25 to 50 mg, 2 to 3 times a day, if tolerated. On the fourth day, the dosage should be 300 to 400 mg a day in 2 or 3 divided doses. If needed, further adjustments in dose should occur at least 2 days apart in increments or decrements of 25 to 50 mg, 2 times a day. Clinical trials have not evaluated daily doses greater than 800 mg."
http://www.wholehealthmd.com/refshelf/drugs_view/0,1524,814,00.html
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Quetiapine Fumarate, Quetiapine Fumarate Treatment of Delirium, 2002 Psychiatric Times:"The analysis indicated that quetiapine was as effective as haloperidol for the treatment of delirium. In fact, quetiapine was better tolerated than haloperidol. None of the patients taking quetiapine, including one with Parkinson's disease, developed EPS, while two patients taking haloperidol developed EPS, leading to discontinuation of the drug. The only adverse condition observed in two of the quetiapine-treated patients was mild-to-moderate sedation."
http://www.psychiatrictimes.com/research.html
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Quetiapine Fumarate, Action/Kinetics, Nurses PDR:" Mechanism unknown but may act as an antagonist at dopamine D2 and serotonin 5HT2 receptors. Side effects may be due to antagonism of other receptors (e.g., histamine H1, dopamine D1, adrenergic alpha-1 and alpha-2, serotonin 5HT1A). Rapidly absorbed. Peak plasma levels: 1.5 hr. Metabolized by liver and excreted through urine and feces. t1/2, terminal: About 6 hr."
http://www.nursespdr.com/members/database/ndrhtml/quetiapinefumarate.html
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