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Prescription Drugs, Medications
Antipyretics, Non Steroidal Anti Inflammatories, NSAIDS, Pain Killers,
Dolobid, Diflunisal

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Diflunisa l (Dolobid) dosage information:drugdigest:"Diflunisal comes as a tablet to take by mouth. It usually is taken two or three times a day. Do not chew or crush the tablets; swallow them whole. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take diflunisal exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. It may take several days for the full effect of this medication to be felt."
http://ww w.drugdigest.org/DD/DVH/HowToTake/0,3919,204|Dolobid,00.html

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Diflunisal (Dolobid) side effects:ahealthyme.com:"Stomach upset, dizziness and drowsiness may occur. If these effects persist or worsen, notify your doctor promptly. Inform your doctor if you develop: black or bloody stools, edema (swelling of the feet or hands), vision changes. Report these rarely occurring side effects promptly: ringing in the ears, hearing loss, dark urine, yellowing of the eyes or skin, easy bruising. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, breathing trouble. If you notice other effects not listed above, contact your doctor or pharmacist"
http://www.ahealthyme.com/viewmonograph?selectedD rugId=218199&selectedDrugDescription=Diflunisal+Oral+Tablet+500+mg

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Instruc tions for taking Diflunisal (Dolobid):gettingwell.com:"Dolobid should be taken with food or food together with an antacid, and with a full glass of water or milk. Never take it on an empty stomach. Tablets should be swallowed whole, not chewed or crushed. Take this medication exactly as prescribed by your doctor. If you are using Dolobid for arthritis, it should be taken regularly. --If you miss a dose...Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time. --Storage instructions...Do not store in damp places like the bathroom"
http:// www.gettingwell.com/drug_info/rxdrugprofiles/drugs/DOL1145.shtml

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When should Diflunisal (Dolobid) not be prescribed?:healthsquare.com:"If you are sensitive to or have had an allergic reaction to Dolobid, aspirin, or similar drugs, or if you have had asthma attacks caused by aspirin or other drugs of this type, you should not take this medication. Make sure that your doctor is aware of any drug reactions that you have experienced. Stomach ulcers and bleeding can occur without warning, especially if you are 65 or older. These and other side effects are also more likely if you have poor kidney function. This drug should be used with caution if you have kidney or liver disease; and it can cause liver inflammation in some people."
http://www.healthsquare.com/newrx /DOL1145.HTM

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Diflunisal (Dolobid) drug class and mechanism:medicinenet:"Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including injury, menstrual cramps, arthritis, and other musculoskeletal conditions. Since the response to different NSAIDs varies from patient to patient, it is not unusual for a doctor to try different NSAIDs for any given condition."
http://www.medicinenet.com/di flunisal/article.htm

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Diflunisal (Dolobid) special considerations:medlineplus:"tell your doctor and pharmacist if you are allergic to diflunisal, aspirin or other medications for arthritis or pain, or any other drugs. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially acetaminophen (Tylenol), anticoagulants ('blood thinners') such as warfarin (Coumadin), cyclosporine (Neoral, Sandimmune), hydrochlorothiazide (Esidrix, HydroDIURIL), indomethacin (Indocin), methotrexate, sulindac (Clinoril), and vitamins. tell your doctor if you have or have ever had hemophilia or other bleeding problems, kidney or heart disease, high blood pressure, or ulcers. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking diflunisal, call your doctor. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking diflunisal. you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you. remember that alcohol can add to the drowsiness caused by this drug. Do not drink alcohol while taking this medication."
U.S. National Library of Medicine
8600 Rockville Pike, Bethesda, MD 20894
custserv@nlm.nih.gov
http://www.n lm.nih.gov/medlineplus/druginfo/medmaster/a684037.html

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Diflunisal (Dolobid) action and kinetics:nursespdr:"A salicylic acid derivative, although not metabolized to salicylic acid. Mechanism not known; may be an inhibitor of prostaglandin synthetase. Onset: 20 min (analgesic, antipyretic). Peak plasma levels: 2-3 hr. Peak effect: 2-3 hr. Duration: 4-6 hr t1/2: 8-12 hr. Ninety-nine percent protein bound. Metabolites excreted in urine. Uses: Analgesic, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriatic arthritis, musculoskeletal pain. Prophylaxis and treatment of vascular headaches. Contraindications: Hypersensitivity to diflunisal, aspirin, or other anti-inflammatory drugs. Acute asthmatic attacks, urticaria, or rhinitis precipitated by aspirin. During lactation and in children less than 12 years of age."
http://www.nu rsespdr.com/members/database/ndrhtml/diflunisal.html

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Diflunisal (Dolobid) drug interactions:personalmd:"Tell your doctor of all over-the-counter and prescription medications you may use, especially "blood thinners" (anticoagulants and antiplatelet drugs such as warfarin, heparins, other NSAIDs)), antacids (regular use), cyclosporine, hydrochlorothiazide (a "water pill") and methotrexate. Do not take acetaminophen, NSAID (e.g., ibuprofen) or aspirin without first consulting your doctor or pharmacist. Check the labels of all your medications carefully. Ask your pharmacist if you are uncertain your other medicines contain these drugs. Do not start or stop any medicine without doctor or pharmacist approval."
http://www.personalmd.com/drgdb/9003.h tm

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Diflunisal (Dolobid) clinical pharmacology:rxlist:"Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties. It is a peripherally-acting non-narcotic analgesic drug. Habituation, tolerance and addiction have not been reported. Diflunisal is a difluorophenyl derivative of salicylic acid. Chemically, diflunisal differs from aspirin (acetylsalicylic acid) in two respects. The first of these two is the presence of a difluorophenyl substituent at carbon 1. The second difference is the removal of the 0-acetyl group from the carbon 4 position. Diflunisal is not metabolized to salicylic acid, and the fluorine atoms are not displaced from the difluorophenyl ring structure. The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues"
http://rxlist.com/cgi/generic3 /diflunisal_cp.htm

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Diflunisal (Dolobid) recommended dosage and overdose:painlab.com:"ADULTS Mild to Moderate Pain Starting dose is 1,000 milligrams, followed by 500 milligrams every 8 to 12 hours, depending on the individual. Your physician may adjust your dosage according to your age and weight, and the severity of your symptoms. Osteoarthritis and Rheumatoid Arthritis The usual dose is 500 to 1,000 milligrams per day in 2 doses of 250 milligrams or 500 milligrams. Use no more than necessary to relieve the pain. The maximum recommended dosage is 1,500 milligrams per day. CHILDREN Safety and effectiveness of Dolobid have not been established in children under 12 years of age. The drug is not recommended for this age group. Overdosage...Any medication taken in excess can cause symptoms of overdose. If you suspect an overdose, seek medical attention immediately. Symptoms of Dolobid overdose may include: Abnormally rapid heartbeat, coma, diarrhea, disorientation, drowsiness, hyperventilation, nausea, ringing in the ears, stupor, sweating, vomiting"
http://www.painlab.com/focus_dolobid.h tm

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