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Ultram (tramadol hydrochloride), Available for purchase online from Pillstore:"For the treatment of painful conditions tramadol 50 mg to 100 mg can be administered as needed for relief every four to six hours, not to exceed 400 mg per day. For moderate pain tramadol 50 mg may be adequate as the initial dose, and for more severe pain, tramadol 100 mg is usually more effective as the initial dose."
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ULTRAM® (tramadol hydrochloride tablets), Ultram.com:"ULTRAM® (tramadol hydrochloride tablets) is a prescription medication indicated for the management of moderate to moderately severe pain. ULTRAM received U.S. Food and Drug Administration (FDA) approval in March 1995. Tramadol has been prescribed in more than 55 million patients worldwide and ULTRAM has been prescribed in more than 21 million patients in the United States. See What is ULTRAM® and How Does It Work? in the Frequently Asked Question section for more information."
http://www.ultram.com/
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Ultram & Fibromyalgia, Fibroworld:"Tramadol in the fibromyalgia syndrome: a controlled clinical trial versus placebo. This study assessed the analgesic action of tramadol compared with placebo in patients suffering from fibromyalgia syndrome. Twelve patients (11 females, one male) were treated according to a double-blind crossover experimental design. Each patient, after signing informed consent, was randomly allocated to either tramadol (100 mg ampul in 100 ml given intravenously in 15 min doses) or placebo for a single dose treatment."
http://hometown.aol.com/fibroworld/ultram.htm
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Ultram brand of TRAMADOL HYDROCHLORIDE, Opioids.com:"Pharmacodynamics Ultram is a centrally acting synthetic analgesic compound that is not derived from natural sources nor is it chemically related to opiates. Although its mode of action is not completely understood from animal tests, at least two complementary mechanisms appear applicable; binding to µ-opioid receptors and inhibition of reuptake of norepinephrine and serotonin. Ultram opioid activity derives from low affinity binding of the parent compound to µ-opioid receptors and higher affinity binding of the M1 metabolite."
http://opioids.com/tramadol/prescribe.html
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Other non-narcotic pain medications (e.g. Ultram), Spine-Health.com:"There is a new type of non-narcotic oral pain medication that can be prescribed to treat low back pain. Tramadol (Ultram) acts centrally (in the brain) to modulate the sensation of pain and has no anti-inflammatory effect. It is a stronger pain reliever than acetaminophen, but probably not as strong as the narcotic agents. Ultram is often a good option for treatment of low back pain because patients do not build up a tolerance with extended usage and there is a very low incidence of addiction."
http://www.spine-health.com/topics/conserv/overview/med/med042.html
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Tramadol Hydrochloride, Ultram - 50 mg tablets, Patient & Family Version, University of Iowa College of Nursing:"After you have taken the medication every 6 hours for 48 hours, your pain should be at a tolerable level. If your pain is not relieved, call your doctor. Do not take a large number of pills at once; this will not achieve faster pain control. Too much of this medication at once could make you very ill or even threaten your life."
http://www.nursing.uiowa.edu/sites/adultpain/Narcs/Tramntch.htm
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Tramadol, RXlist.com:"Tramadol is a centrally acting synthetic analgesic compound. Although its mode of action is not completely understood, from animal tests, at least two complementary mechanisms appear applicable: binding of parent and M1 metabolite to m-opioid receptors and weak inhibition of reuptake of norepinephrine and serotonin. Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to m-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in m-opioid binding. Tramadol-induced analgesia is only partially antagonized by the opiate antagonist naloxone in several animal tests. The relative contribution of both tramadol and M1 to human analgesia is dependent upon the plasma concentrations of each compound (see Pharmacokinetics)."
http://www.rxlist.com/cgi/generic/tramadol_cp.htm
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