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Talwin,
Talwin NX(Pentazocine)Pharmacokinetics and contraindications: 48 hours:
"Absorption: readily absorbed from GI tract; 20% reaches systemic circulation
(first pass metabolism). Onset: 15–30 min PO, IM, SC; 2–3 min IV. Peak: 1–3 h
PO, IM; 15 min IV. Duration: 3 h PO, IM; 1 h IV. Distribution: crosses placenta.
Metabolism: extensively metabolized in liver. Elimination: half-life: 2–3 h;
excreted primarily in urine; small amount in feces.Contraindicated in: head
injury, increased intracranial pressure; emotionally unstable patients, or
history of drug abuse. Safe use during pregnancy (other than labor) (category C)
and in children 12 y not established. Cautious use in: impaired renal or hepatic
function; respiratory depression; biliary surgery; patients with MI who have
nausea and vomiting."
http://www.48hours.net/plweb-cgi/fastweb.exe?getdoc+Guide+Guide+812+0+++PENTAZOCINE+adj+HYDROCHLORIDE%3ADRUGNAME
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Talwin
(Pentazocine) description and comprehensive drug information:Rx List:
"TALWIN Nx contains pentazocine hydrochloride, USP, equivalent to 50 mg base and
is a member of the benzazocine series (also known as the benzomorphan series),
and naloxone hydrochloride, USP, equivalent to 0.5 mg base. TALWIN Nx is an
analgesic for oral administration. Chemically, pentazocine hydrochloride is 1,
2, 3, 4,5,6-Hexahydro- 6,11-dimethyl-3-(3-
methyl-2-butenyl)-2,6-methano-3-benzazocin-8- ol hydrochloride, a white,
crystalline substance soluble in acidic aqueous solutions.Chemically, naloxone
hydrochloride is Morphinan-6-one, 4, 5-epoxy-3, 14-dihydroxy-17- (2-propenyl)-,
hydrochloride, (5a). It is a slightly off-white powder, and is soluble in water
and dilute acids. Inactive Ingredients: Colloidal Silicon Dioxide, Dibasic
Calcium Phosphate, D&C Yellow #10, FD&C Yellow #6, Magnesium Stearate,
Microcrystalline Cellulose, Sodium Lauryl Sulfate, Starch."
http://arthritis.about.com/gi/dynamic/offsite.htm?site=http%3A%2F%2Fwww.rxlist.com%2Fcgi%2Fgeneric%2Fpentazocine.htm
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NURSING
IMPLICATIONS for patients taking Talwin (Pentazocine): Harcourt Health:
"BASELINE ASSESSMENT: Raise bed rails. Obtain vital signs before giving
medication. If respirations are 12/min or lower, withhold medication, contact
physician. Assess onset, type, location, and duration of pain. Effect of
medication is reduced if full pain recurs before next dose.
INTERVENTIONS/EVALUATION: Encourage deep breathing and coughing exercises. Check
vital signs periodically (5-10 min after IV dose). Monitor for change in
respirations, B/P, change in rate/quality of pulse. Initiate deep breathing and
coughing exercises, particularly in those with impaired pulmonary function.
Change pt's position q2-4h. Assess for clinical improvement and record onset of
relief of pain. Contact physician if pain is not adequately relieved.
PATIENT/FAMILY TEACHING: Change positions slowly to avoid dizziness. Head-low
position may help relieve lightheadedness, nausea. Explain need for assistance
if ambulating. Avoid alcohol. Request pain medication before pain fully recurs."
http://www.harcourthealth.com/SIMON/SaundersNDH/update_trade_frame.html
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Available
forms of Talwin (Pentazocine): University of Iowa Nursing: "Talacen
(Pentazocine HCL 25 mg with acetaminophen 650 mg) Talwin Nx (Pentazocine HCL 50
mg with Naloxone 5 mg) Talwin Compound (Pentazocine HCL 12.5 mg with aspirin 325
mg) Talwin (Pentazocine lactate 30 mg) The form you are taking is written on the
label of your prescription. If you are unsure of the form you have, call your
nurse, pharmacist or doctor.TELL your doctor, nurse, and pharmacist if you:have
allergies. are pregnant or plan to become pregnant. are breast-feeding. are
taking ANY other medicine, including those you buy yourself such as aspirin or
cold medicine. Taking other medicine that contains acetaminophen or a narcotic
while you are taking this medicine may lead to overdose. have ANY other medical
problems. Talwin in all forms is a prescription drug.Route: Talacen, Talwin Nx,
and Talwin Compound are taken by mouth.Talwin (Pentazocine lactate) is taken as
a shot. Use: For mild to severe pain."
http://www.nursing.uiowa.edu/sites/adultpain/MixedAge/Talwinnt.htm
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Clinical
Pharmacology of Talwin (Pentazocine): CTCL Consult: "Pentazocine is a potent
analgesic which when administered orally in a 50 mg dose appears equivalent in
analgesic effect to 60 mg (1 grain) of codeine. Onset of significant analgesia
usually occurs between 15 and 30 minutes after oral administration, and duration
of action is usually three hours or longer. Onset and duration of action and the
degree of pain relief are related both to dose and the severity of pretreatment
pain. Pentazocine weakly antagonizes the analgesic effects of morphine and
meperidine; in addition, it produces incomplete reversal of cardiovascular,
respiratory, and behavioral depression induced by morphine and meperidine.
Pentazocine has about 1/50 the antagonistic activity of nalorphine. It also has
sedative activity.Pentazocine is well absorbed from the gastrointestinal tract.
Concentrations in plasma coincide closely with the onset, duration, and
intensity of analgesia; peak values occur 1 to 3 hours after oral
administration. The half-life in plasma is 2 to 3 hours.Pentazocine is
metabolized in the liver and excreted primarily in the urine. Pentazocine passes
into the fetal circulation.Naloxone when administered orally at 0.5 mg has no
pharmacologic activity. Naloxone hydrochloride administered parenterally at the
same dose is an effective antagonist to pentazocine and a pure antagonist to
narcotic analgesics."
http://www.ctclconsult.com/pdrdruginfo/html/73003900.htm
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Talwin
(Pentazoncine) Contraindicated in some patients: A Healthy Me: "Naloxone and
pentazocine is habit forming. If you have an alcohol or drug addiction, this
medication should only be used only under close medical supervision. Before
taking this medication, tell your doctor if you have kidney disease; liver
disease; asthma; urinary retention; an enlarged prostate; hypothyroidism;
seizures or epilepsy; gallbladder disease; a head injury; or Addison's
disease.You may not be able to take naloxone and pentazocine, or you may require
a dosage adjustment or special monitoring during treatment if you have any of
the conditions listed above.Naloxone and pentazocine is in the FDA pregnancy
category C. This means that it is not known whether naloxone and pentazocine
will harm an unborn baby. Naloxone and pentazocine may cause addiction and
withdrawal symptoms in an unborn baby. Do not take naloxone and pentazocine
without first talking to your doctor if you are pregnant. It is not known
whether naloxone and pentazocine passes into breast milk. This medication may
cause addiction and withdrawal symptoms in a nursing infant."
http://www.ahealthyme.com/topic/topic100592164
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