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Darvocet
(Propoxyphene Napsylate): Mosby's GenRx: "Darvocet is an opioid analgesic
used to treat mild to moderate pain…The CNS-depressant effect of propoxyphene is
additive with that of other CNS depressants, including alcohol. Because of the
potent nature of this medicine, be sure to tell your doctor about any other
medicines you are taking, including nonprescription medicines and
vitamins."
http://jraworld.arthritisinsight.com/medical/meds/darvocet.html
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Darvocet
(Propoxyphene Napsylate): PDR® Family Guide To Prescription Drugs®: "The
propoxyphene in these drugs slows down the central nervous system and
intensifies the effects of alcohol. Heavy use of alcohol with this drug may
cause overdose symptoms. If these medications are taken with certain other
drugs, the effects of either could be increased, decreased, or altered. It is
especially important to check with your doctor before combining them with the
following: Antiseizure medications such as Tegretol, Antidepressant drugs such
as Elavil, Antihistamines such as Benadryl Muscle relaxants such as Flexeril,
Narcotic pain relievers such as Darvocet, Sleep aids such as Halcion,
Tranquilizers such as Xanax and Valium, Warfarin-like drugs such as Coumadin.
The use of these drugs with propoxyphene can lead to potentially fatal overdose
symptoms."
http://www.healthsquare.com/pdrfg/pd/monos/darvocet.htm
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Side
Effects of Darvocet (Propoxyphene Napsylate): Harvard Medical School
Consumer Health Information: "You should see your doctor regularly for tests and
examinations if you take this medication for a prolonged period. Prolonged use
can cause nerve damage as well as physical dependence. Adverse reactions may be
more likely and more severe in older patients. Propoxyphene has not caused birth
defects in animals. Human studies have not been done. Before you use this
medication, tell your doctor if you are pregnant or plan to become pregnant.
Overuse of the medication during pregnancy can cause physical dependence in the
newborn."
http://www.intelihealth.com/IH/ihtIH?d=dmtSimple&c=214240&p=~br,AOL|~st,8124|~r,WSAOL002|~b,*|
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Considerations and contraindications of Darvocet N-100 (Propoxyphene Napsylate): AgeNet, Inc: "Caution is advised for use in the elderly since they are more susceptible to the depressant effects on the central nervous system (i.e. confusion, sedation, dizziness). Also, people with compromised kidney or liver function must use extreme caution since small doses of Darvocet N-100 could have increased effect/toxicity."http://agenet.agenet.com/?Url=link.asp?DOC/1311
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Darvocet
(Propoxyphene Napsylate); Action: MedicineNet Inc: "It works by affecting
the brain's perception of pain. Propoxyphene is often combined with TYLENOL as
in DARVOCET-N, or with ASPIRIN as in DARVON COMPOUND- 65 to achieve more
effective pain relief. Since propoxyphene is often combined with TYLENOL or
ASPIRIN, patients should be aware of the precautions and side effects related to
the other two medications. SIDE EFFECTS: The most frequent side effects include
dizziness, sedation, nausea, and vomiting. Other side effects include
constipation, abdominal pain, rash, headache, and hallucinations."
http://www.medicinenet.com/Script/Main/Art.asp?li=MNI&ArticleKey=732
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Absorption and
metabolism of Darvocet (Propoxyphene Napsylate): Traumatic Brain Injury
Resource Guide: "Peak plasma concentrations are reached in 2-2 1/2 hours.
Metabolism: Metabolized in the liver by microsomal enzymes. Half-life: 6-12
hours. The CNS-depressant effect of propoxyphene is additive with that of other
CNS depressants, including alcohol. Propoxyphene may slow the metabolism of a
concomitantly administered drug."
http://www.neuroskills.com/index.html?main=tbi/pain.html
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Darvocet
(Propoxyphene Napsylate) dosage indications: Delmar, A division of learning:
"Nonnarcotic analgesic: Acetaminophen, 325 (Darvocet-N 50) or 650 mg (Darvocet-N
100). Analgesic: Propoxyphene napsylate, 50 or 100 mg. Tablets Analgesia. Two
Darvocet-N 50 tablets or 1 Darvocet-N 100 tablet q 4 hr, not to exceed 600
mg/day of propoxyphene napsylate. Reduce total daily dose in impaired hepatic or
renal function."
http://www.nursespdr.com/members/database/ndrhtml/darvocetn50anddarvocetn100.html
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Toxicity and
overdose with Darvocet (Propoxyphene Napsylate): Mosby Inc: "Propoxyphene
products in excessive doses, either along or in combination with other CNS
depressants, including alcohol, are a major cause of drug-related deaths.
Fatalities within the first hour of over dosage are not uncommon. In a survey of
deaths due to over dosage conducted in 1975, in approximately 20% of the fatal
cases, death occurred within the first hours (5% occurred within 15
minutes)."
http://www.rxlist.com/cgi/generic/propox_wcp.htm
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