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Morphine Sulfate, Narcotic Analgesics, Pain Killers, Controlled Substances

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The Shortcut URL To This Page Is http://www.jokesnjokes.net/morphine/

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Morphine Sulfate; an interesting article applauding nursing care in Oregon: Nurseweek.com: "Increased use of morphine reflects care providers' attention to pain relief.' A third of deaths in Oregon occur in nursing homes, and studies have shown that 40 to 60 percent of nursing home patients do not receive adequate pain medication, Tolle said. "We're pleased to see more attention being given to comfort near the time of death," she said. Oregon has made it easier to prescribe narcotics by not requiring cumbersome paperwork, she said. Super encouraged nurses to advocate pain management for their patients. "We think about pain being in the physicians' realm, but nurses can have a significant impact," she said."
http://www.nurseweek.com/news/morph.html

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Morphine Sulfate: A Healthy Me: "Morphine is habit forming and should only be used under close supervision if you have an alcohol or drug addiction. Before taking this medication, tell your doctor if you have kidney disease, liver disease, asthma, urinary retention, an enlarged prostate hypothyroidism, seizures or epilepsy, gallbladder disease, a head injury, or Addison's disease. You may not be able to take morphine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. Morphine may cause addiction and withdrawal symptoms as well as other harmful effects in an unborn baby. Do not take morphine without first talking to your doctor if you are pregnant. Morphine may also cause addiction and withdrawal symptoms in a nursing infant. Do not take morphine without first talking to your doctor if you are breast-feeding a baby. If you are younger than 18 years of age or older than 60 years of age, you may be more likely to experience side effects from morphine therapy. Use extra caution.
http://www.ahealthyme.com/topic/topic100590921

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Structure of Morphine Sulfate: "Morphine is obtained from opium, the juice secreted by the seeds of the poppy. It works on several types of receptors, widely found in nervous tissue. "Opioids" is a term used for all drugs that act on these receptors. These other opioids may be natural occurring substances, such as morphine, or made in the laboratory such as pethindine." Morphine works on receptors in the cell membranes. These are protein-lipid molecules that alter their shape when stimulated to effect molecular changes within cells. There are thought to be three types of receptors that respond to opioids, mu, kappa and lambda. Morphine acts mainly on mu receptors to cause a wide variety of effects. The most important of these are relief of pain and respiratory depression."
http://leda.lycaeum.org/Chemicals/Morphine.159.shtml

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High risk categories-Morphine Sulfate: Infomed-Verlags AG: "Pregnancy-Generally the administration is allowed for medical indications. However, at term there are significant risks for the neonate (respiratory depression, cardiac problems): avoid morphine! Nursing mothers: Only small amounts can be traced in breast milk. Can be given, may suppress lactation! Children: Single dose: 0.1 to 0.2 mg/kg (i.m./s.c. every 4 hours), as infusion 10-30 µg/kg/hour. Long half-lives in neonates! (Fentanyl may be better tolerated.) Elderly people: Elderly people have a stronger reaction to morphine: reduce dose! Renal failure: A dose reduction is recommended (active metabolites may be important). Liver insufficiency: Generally no problem. A dose reduction is nevertheless recommended if disease is advanced"
http://www.infomed.org/100drugs/morfrg.html

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Tolerance with patients taking Morphine Sulfate: AANA/CNS pain newsletter: "One of the most troublesome issues is that of tolerance to the agent used in the pump. Opioid tolerance is said to be universal; that is, everyone is expected to experience dose escalation as time goes on. What is not clear is the degree to which such tolerance interferes with therapy in the long term."
http://www.ohsu.edu/som-neurosurgery/news/vol51/morphine.html

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Hospice information given with table of contents regarding patients with breathing problems who receive morphine sulfate (comprehensive list of pages): Steven J Baumrucker, MD: "Nebulized Morphine and the Management of Terminal Dyspnea. Terminal Dyspnea often does not respond to standard therapy. Etiology of Dyspnea in Terminal Patients. Direct Tumor Effects. Indirect Tumor Effects. Treatment Related Causes. Problems unrelated to terminal diagnosis. Diagnosis. Diagnostic Tests. Treat specific cause of dyspnea if possible (or indicated)…."
http://hospice.xtn.net/dyspnea/

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Morphine Sulfate: Pain Research and Nuffield Department of Anesthetics University of Oxford, UK: "'Dose-corrected plasma concentrations for Morphine, MG3 and MG6 for patients with normal renal and hepatic function.' The chapter outlines some features of opioid pharmacology, and then details the chemistry, analytical methodology, metabolism, body fluid concentration and influence of pathophysiology on drug metabolism and excretion of morphine. The chapter considers the structure-activity relationships of the morphine molecule in some detail, because of the implications that the active metabolite morphine-6-glucuronide has for clinical practice. The emphasis is the clinical importance of features of the drug's metabolism, toxic or active metabolites, and the practical influence of pathophysiology."
http://www.jr2.ox.ac.uk/bandolier/booth/painpag/wisdom/c14.html

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