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Demerol
(Meperidine): The PIENO Parkinsn's List Drug Database: "Meperidine
hydrocholoride is an oral and parenteral opiate agonist. In foreign countires,
it is known as pethindine. Meperidine is not a natural opiate like morphine or
codeine, but is a synthetic compound belonging to the phenylpiperidine class.
Meperidine is recommended for relief of moderate to severe pain but also has the
unique ability to interrupt postoperative shivering and shaking chills induced
by amphotericin B. Meperidine is metabolized to normeperidine, a compound
capable of inducing seizures if it accumulates. Unlike morphine, which was in
use long before the passage of the 1938 FD&C act, meperidine was first
approved by the FDA and marketed in 1942. It is a schedule C-II controlled
substance and is available in both oral and parenteral forms. "
http://www.parkinsons-information-exchange-network-online.com/drugdb/079.html
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Description Of
Meperidine (Demerol) with comprehensive drug information: Rx List:
"Meperidine hydrochloride injectable is supplied in Carpuject with InterLink and
Carpuject Sterile Cartridge-Needle Units, SmartPak Injection Delivery System of
2.5% (25 mg/1 ml), 5% (50 mg/1 ml), 7.5% (75 mg/1 ml), and 10% (100 mg/1 ml).
Uni-Amp Unit Dose Pak--ampuls of 5% solution (25 mg/0.5 ml), (50 mg/1 ml), (75
mg/1.5 ml), (100 mg/2 ml), and 10% solution (100 mg/1 ml). Uni-Nest Pak--ampuls
of 5% solution (25 mg/0.5 ml), (50 mg/1 ml), (75 mg/1.5), (100 mg/2 ml), and 10%
solution (100 mg/1 ml). Multiple-dose vials of 5% and 10% solutions contain
metacresol 0.1% as preservative.The pH of meperidine solutions is adjusted
between 3.5 and6 with sodium hydroxide or hydrochloric acid."
http://www.rxlist.com/cgi/generic/meper.htm
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Overdose
considerations concerning Demerol (Meperidine) and it's use:
HeadachePainFree.Com: "'Even patients with no known risk factors may develope
Meperidine-induced toxicity' 'For more than 10 years, clinical practice
guidelines, such as those developed by the American Pain Society, have included
warnings about the hazards of meperidine use in pain management. Yet Meperidine,
a short-acting morphine-like opioid, continues to be the parenteral opioid most
frequently prescribed for moderate to severe pain.'"
http://www.headachepainfree.com/meperidine.htm
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Demerol
(Meperidine) Toxicity: Health Central: "Children are more susceptible to
some of the side effects of these medications including: breathing problems
excitability restlessness Children should not receive more than the prescribed
amount. Do not double up the dose or increase the dose without consulting with a
health care provider. Use a calibrated medicine spoon to administer the liquid
medication to assure accuracy. Sedation is a common side effect, physical
activities that require mental alertness should be avoided. These compounds can
cause constipation; fiber or a stool softener may be needed."
http://www.healthcentral.com/mhc/top/002624.cfm
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Demerol
(Meperidine) Use; a study of complience with national guidelines: The Good
Drug Guide: "The Agency for Health Care Policy and Research (AHCPR) established
guidelines for the use of meperidine (demerol), a common inpatient analgesic.
These guidelines define standards of care for acute and chronic cancer pain
management and address many of the problems with meperidine and its metabolite,
normeperidine. The purpose of this study was to determine whether meperidine was
prescribed in compliance with AHCPR guidelines, whether patients exhibited any
adverse reactions to meperidine, and to determine the analgesic efficacy of
meperidine."
http://www.opioids.com/meperidine/structure.html
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Meperidine
(Demerol) Pain Control Issues "The Passing of Demerol": West Virginia Cancer
Pain Initiative: "Meperidine (Demerol) has been the traditional analgesic drug
for many years. Several misconceptions have lead meperidine to the established
place as the standard agent for pain control. In truth, Meperidine is distinctly
inferior for pain control, an irritant at the site of injection, ineffective
orally, and has a dangerous toxic metabolite which can accumulate at standard
doses. Serious questions must be raised about the continued use of Meperidine
view of its poor effectiveness and high incidence of serious side
effects."
http://ruralnet.marshall.edu/pain/demerol.htm
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Demerol
(Meperidine); Nursing Considerations: Midwest Anesthesia Consultants: "On
this page, you will find information which will enable YOU as the clinical
nursing expert, to have physician orders changed to safer alternatives for your
patient's pain. When your rational for requesting the change from Demerol to
another opioid is clear and scientifically based, most physicians will listen.
Three hundred inpatient charts were reviewed and identified meperidine as the
primary analgesic in 157 nonobstetric inpatients. Age, sex, weight, dosing
interval, route of administration, duration of meperidine use, serum chemistry
values, primary diagnosis, associated medical conditions, and medications
concurrently being taken with meperidine were the parameters analyzed."
http://www.jackstem.com/demerol_dangers.htm
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