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Comparison of
Bupernex to Methadone for treatment of pain : "Opioids.com: As a maintenance
agent for opioid dependency, buprenorphine offers advantages such as a lower
level of dependence and minimal withdrawal symptoms, due to its partial agonist
properties at the micro-opioid receptor. Previous studies have shown 8 mg
sublingual buprenorphine to be equivalent to 60 mg oral methadone in terms of
retention rate and opioid-negative urine levels. In a 24-week, ongoing European
study, 34 opioid-dependent subjects were assessed; 16 receiving buprenorphine
and 18 methadone. A free dosing schedule was used with no upper limit for
methadone dosing but with a maximum buprenorphine dose of 8 mg."
http://www.opioids.com/buprenorphine/index.html
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Doctor's give information about Butrenex, Buprenorphine Hydrochloride : cprflorida.com: "Buprenorphine hydrochloride, sold under the tradename Buprenex® by Rheckitt & Coleman, Ltd., acts as a partial Mu agonist, meaning it has components for analgesia and pain relief but, uniquely, is also a full Kappa antagonist. Because of this property, Buprenex® is outstanding for management of short-term and chronic pain. It is provenly effective for opiate detoxification, with a minimum of commonly associated discomfort. During detoxification, Buprenex® allows comfortable, painless withdrawal, without the fatigue, sweats, tactile sensation complaints ("tingling" or "skin crawling"), aches, seizure risk or confused thought processes common during traditional detoxification procedures. "A greater potential than Methadone to safely and effectively block the actions of opioids, with virtually no withdrawal symptoms."cprflorida.com/clinicals.htm ******************************************************
Buprenex,
Buprenorphine HCL: North Carolina Board of Pharmacy: "There appears to be a
misunderstanding that Buprenex can be used in the treatment of opiate addiction
as an 'off label' use of an approved drug product," the letter stated.
"Practitioners who dispense Buprenex for the treatment of opiate addiction must
comply with the Narcotic Addict Treatment Act (NATA) (21 USC 823(g)). Buprenex
may not be used for the treatment of opiate addiction unless and until it is
approved for this use and there are standards in place to permit practitioners
to be registered by DEA as required by NATA."
http://us.f205.mail.yahoo.com/ym/ShowLetter/www.ncbop.org/jan01-5.asp
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Buprenex,
Buprenorphine database information: Walgreens Pharmacy: "Common Uses: This
medicine is a narcotic analgesic used to treat or prevent moderate to severe
pain. It may also be used to treat other conditions as determined by your
doctor. How to use this Medicine: This medicine is sometimes used at home as an
injection. Before using this medicine, a healthcare professional will provide
detailed instructions for appropriate use of this medicine. Ask any questions
that you may have about this medicine or giving injections. STORE THIS MEDICINE
as directed on the prescription label. IF YOU MISS A DOSE OF THIS MEDICINE and
you are using it regularly, use it as soon as possible. If it is almost time for
your next dose, skip the missed dose and go back to your regular dosing
schedule. Do not use 2 doses at once."
http://www.walgreens.com/library/finddrug/druginfo.jhtml?_DARGS=%2Flibrary%2Ffinddrug%2Finfosearchresults.jhtml.27_A&_DAV=12182
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Study
involving treatment with Buprenex (Buprenorphine): Doctor's Guide:
"Opioid-dependent outpatients may be more likely to present for pharmacological
treatment if less than daily dosing can be arranged. These studies compared
opioid withdrawal symptoms during 24-, 72-, and 120-hour buprenorphine dosing
regimens and evaluated participants' preferences for these different dosing
regimens. Participants. Thirty-three opioid-dependent participants received
daily sublingual maintenance doses of 4 mg/70 kg (n = 14) or 8 mg/70 kg (n = 19)
of liquid buprenorphine. Methods. In Study I participants received, in a random
order, three dosing regimens for five repetitions of each: daily maintenance
doses every 24 hours (4 or 8 mg/70 kg), triple the daily maintenance dose every
72 hours (12 or 24 mg/70 kg) and quintuple the daily maintenance dose every 120
hours (20 or 40 mg/70 kg). Doses were administered under double-blind
procedures, and placebos were administered on the interposed days during the
latter two regimens. "
http://www.docguide.com/news/content.nsf/PaperFrameSet?OpenForm&id=48DDE4A73E09A969852568880078C249&newsid=8525697700573E1885256A73005B2C2F&u=http://rosina.catchword.com/cgi-bin/cgi?ini=carfax&body=linker&reqidx=/catchword/carfax/13600443/v96n6/s4/p823&ref=/news/content.nsf/news/8525697700573E1885256A73005B2C2F?OpenDocument&id=48DDE4A73E09A969852568880078C249&count=10&highlight=0,buprenex
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