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Aldara, (Imiquimod), 3M:"Product Overview: ALDARA (imiquimod) Cream, 5% Is The Newest Way To Treat External Genital Warts. ALDARA cream is used to treat external genital and perianal warts and is different from most other treatments. It is a patient-applied cream that helps the body fight the virus instead of just getting rid of the warts. So ALDARA cream actually treats warts from the inside out. In a recent survey of patient and physician treatment preferences, patients reported better overall satisfaction, more convenience and less associated pain with Aldara than with previously used therapies for genital warts. Physicians also rated Aldara as preferable to other treatments in terms of convenience, less associated pain and patient compliance."
http://www.3m.com/us/healthcare/pharma/aldara/con_overview.jhtml
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Aldara, (Imiquimod), Society of Health Advisers in Sexually Transmitted Diseases (SHASTD):"How to use Aldara: the cream should be applied no more than three times per week until the warts clear or for a maximum of 8 weeks. Apply the cream on alternate nights i.e. Monday, Wednesday, Friday. Wash your hands before applying Aldara cream. Put a little of the cream onto your fingertip and rub it into the wart/s. Throw away any remaining cream in the open sachet. Wash your hands thoroughly after use, paying particular attention to your fingertips, although Aldara does not harm the fingers. You MUST wash off the cream in 6 to 10 hours. If, in men, the warts are under the foreskin, it should be pulled back and the area washed thoroughly."
http://www.shastd.org.uk/medications/imiqu.htm
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Aldara, (Imiquimod), WebMD, Inc.:"Warts and Plantar Warts. Imiquimod (Aldara) for warts. Imiquimod (Aldara) is an immunotherapy that stimulates the body's natural defense system (immune system), causing it to attack the wart. It appears that this medication works by starting a local inflammatory response in the skin. When the body reacts to the medication by producing inflammatory chemicals (cytokines) in the affected area, the wart is eventually destroyed. Aldara is applied to the skin and can be used at home once you have been instructed how to safely use it by your doctor."
http://my.webmd.com/content/healthwise/134/33245.htm?lastselectedguid={5FE84E90-BC77-4056-A91C-9531713CA348}
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Aldara, (Imiquimod), Centerwatch:"Additional Information: Genital warts is a sexually transmitted disease (STD) caused by the human papilloma virus (HPV). HPV is one of the most common - and least talked about - of all STDs; at least 10 to 20 percent of sexually active Americans are thought to be infected. Genital warts is growing at a rate of 750,000 new cases each year, is spread by sexual contact with an infected partner and is highly contagious. This life long virus can cause warts in the genital and perianal areas in females and males. Male sexual partners of infected women often have HPV penile infection. Genital warts may cause itching, burning, pain and tenderness. Although there is no cure for genital warts, treatment can alleviate physical symptoms and psychological reactions such as problems with sexuality, shame, embarrassment and self-blame."
http://www.centerwatch.com/patient/drugs/dru238.html
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Aldara, (Imiquimod), Doctor's Guide:"New findings from a recent, international,open-label study reaffirm that the patient-applied treatment, Aldara™ (imiquimod) Cream, 5%, is safe and effective for eradicating external genital warts -- the results of which are reflective of a real-life clinic setting. The study reports that the efficacy of Aldara in 943 male and female patients of different ethnic backgrounds was similar to that in previous randomized, vehicle-controlled studies, according to the International Journal of STD & AIDS. (1),(2),(3) This international trial is the first published study that investigates the efficacy of a topical therapy for external genital warts in such a large group of patients -- in 114 clinics across five continents (Europe, Canada, Latin America, Australia and South Africa). Patients whose warts decreased in size but did not totally clear in the initial 16 weeks of therapy (191, 20 percent), were offered the option to apply Aldara for
up to an additional 16 weeks. This resulted in total clearance in 33 percent of these patients. This continued application of Aldara was well-tolerated by patients, and this study highlights that the frequency of application site reactions was, indeed, lower in the second treatment cycle compared to the initial 16 weeks of therapy."
http://www.docguide.com/dg.nsf/PrintPrint/743D6C3FED64797785256B200061056B
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Aldara, (Imiquimod), Dermatology OnlLine Journal:"Abstract: The objective of this study was to evaluate the safety of imiquimod 5% cream, a potent inducer of interferons, in children with molluscum contagiosum. The lesions of thirteen subjects (mean age 7 years) were treated every night for 4 weeks. A visual analog scale was used to assess any adverse local skin reactions, and for the presence of systemic side effects characteristic of interferon (IFN). Temperature and total white blood cell count were measured at baseline and compared with results at weeks 2 and 4. In the twelve subjects who completed the study, adverse reactions were limited to application site reactions. We did not find any evidence of systemic toxicity. In conclusion, imiquimod 5% cream appears to be a safe treatment in children with molluscum contagiosum."
http://dermatology.cdlib.org/DOJvol7num1/therapy/imiquimod/berman.html
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Aldara, (Imiquimod), Health Science Report:"Interventions: Five percent (5%) imiquimod (Aldara) cream, 1% imiquimod cream, or vehicle cream was applied to all external warts overnight 3 times each week for 16 weeks, or until all treated warts disappeared, whichever occurred first. Main Outcome Measurements: The number of patients experiencing the elimination of all baseline warts and the recurrence rate of these warts. In addition, the reduction in baseline wart area the duration of therapy required to eliminate warts, and the frequency and severity of adverse reactions were principal measurements."
http://www.alotek.com/hpv/traditional-treatments-for-warts.shtml
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Aldara, (Imiquimod), Department of Medicines Management:"Current treatment options. Left untreated, anogenital warts may resolve on their own (in 10-30% of patients), remain unchanged, or increase in size or number; they rarely become malignant.2,3 The primary goal of treatment is to remove warts that cause physical or emotional symptoms. Various treatment options are available for the treatment of anogenital warts. No single treatment appears superior, in terms of clearance or prevention of recurrence, and no single treatment is ideal for all patients or all warts. Most available treatments are directed at the wart rather than the virus. They include cytotoxic substances such as podophyllum resin, its active constituent podophyllotoxin, and trichloroacetic acid. Physical treatments include cryotherapy, laser therapy and surgical excision. With the exception of podophyllotoxin, these treatments require administration by a physician or trained personnel."
http://www.keele.ac.uk/depts/mm/MTRAC/ProductInfo/summaries/I/IMIQUIMODs.html
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