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Desmopressin acetate, CenterWatch, Inc.:"Diabetes insipidus is a rare metabolic disorder in which patients produce large quantities of dilute urine and are constantly thirsty. CDI is caused by a deficiency in the amounts of the hormone vasopressin secreted from the pituitary gland, and can be caused by disease of the gland, or by injury to the gland such as head trauma, surgery, or tumors. The condition can be acute and short in duration or it can be a chronic, life-long problem. According to the National Center for Health Statistics, there were 11,000 hospital discharges in the United States in 1992. The number of CDI subjects on therapy outside of the hospital setting is more difficult to measure."
http://www.centerwatch.com/patient/drugs/dru54.html
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Desmopressin acetate, DrugDigest:"Desmopressin is a chemical that is similar to a hormone found naturally in your body. It increases urine concentration and decreases urine production. Desmopressin is used to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions, allowing you to sleep through the night without awakening to urinate. It is also used to treat specific types of diabetes insipidus and conditions after head injury or pituitary surgery. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information."
http://www.drugdigest.org/DD/DVH/Uses/0,3915,194|Desmopressin,00.html
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Desmopressin acetate, Mayo Foundation for Medical Education and Research:"Desmopressin (des-moe-PRES-in) is a hormone taken through the nose, by mouth, or given by injection to prevent or control the frequent urination, increased thirst, and loss of water associated with diabetes insipidus (water diabetes). It is used also to control bed-wetting and frequent urination and increased thirst associated with certain types of brain injuries or brain surgery. Desmopressin works by acting on the kidneys to reduce the flow of urine. Desmopressin is also given by injection to treat some patients with certain bleeding problems such as hemophilia or von Willebrand's disease."
http://www.mayoclinic.com/findinformation/druginformation/druginvoke.cfm?objectId=0009D94F-7A99-1B79-AB8080AEBC2F0839
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Desmopressin acetate, MEDLINEplus:"Desmopressin is a chemical that is similar to a hormone found naturally in your body. It increases urine concentration and decreases urine production. Desmopressin is used to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions, allowing you to sleep through the night without awakening to urinate. It is also used to treat specific types of diabetes insipidus and conditions after head injury or pituitary surgery. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information."
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682876.html
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Desmopressin acetate, MediResource.com:"Bedwetting: The dose needs to be individualized according to needs. The usual starting dose is 20 µg (0.2 mL) of nasal spray used one hour before sleep. The average effective dose ranges from 10 µg to 40 µg. It is recommended that fluid intake be restricted for a few hours before taking the drug. Bleeding disorders: When used for bleeding disorders, desmopressin is given by intravenous (into the vein) infusion. The typical adult dose is 10 µg per square meter of body surface area, with a maximum dose of 20 µg. For children, the usual dose is 0.3 µg per kilogram of body weight."
http://drugs.medbroadcast.com/ASP/DrugInfo.asp?BrandNameID=746
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Desmopressin acetate, Nurses's PDR Resource Center:"Side Effects: DDAVP: Intranasal: Transient headaches, nausea, nasal congestion, rhinitis, facial flushing, asthenia, chills, conjunctivitis, cough, dizziness, epistaxis, eye edema, GI disorder, lacrimation, nosebleed, nostril pain, sore throat, URIs. Parenteral: Mild abdominal pain, facial flushing, transient headache, nausea, vulval pain, BP changes, burning pain, edema, local erythema, anaphylaxis (rare). Stimate: Intranasal: Agitation, balanitis, chest pain, chills, dizziness, dyspepsia, edema, insomnia, itch or light-sensitive eyes, pain, palpitations, somnolence, tachycardia, vomiting, warm feeling. Overdose Management: Symptoms: Headache, abdominal cramps, facial flushing, dyspnea, fluid retention, mucous membrane irritation. Treatment: Reduce dose, decrease frequency of administration, or withdraw the drug depending on the severity of the condition."
http://www.nursespdr.com/members/database/ndrhtml/desmopressinacetate.html
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Desmopressin acetate, RxList:"Adults and Children: It is recommended that patients be started on doses of 0.05 mg (1/2 of the 0.1 mg tablet) two times a day and individually adjusted to their optimum therapeutic dose. Most patients in clinical trials found that the optimal dosage range is 0.1 mg to 0.8 mg daily, administered in divided doses. Each dose should be separately adjusted for an adequate diurnal rhythm of water turnover. Total daily dosage should be increased or decreased in the range of 0.1 mg to 1.2 mg divided into two or three daily doses as needed to obtain adequate antidiuresis. See PRECAUTIONS: Pediatric Use subsection for special considerations when administering desmopressin acetate to pediatric diabetes insipidus patients."
http://www.rxlist.com/cgi/generic3/desmoprt_ids.htm
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Desmopressin acetate, The Online Medical Network Inc.:"How to take: Nasal spray: Fill the rhinyle (a flexible, calibrated catheter) with a measured dose of the nasal spray. Blow on the other end of the catheter to deposit the solution deep into the nasal cavity. For infants and children, an air-filled syringe may be used. When to take: At the same time each day, according to instructions on prescription label."
http://www.mdadvice.com/library/drug/drug149.html
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Desmopressin acetate, WholeHealthMD:"For diabetes insipidus-- Injection: 2 to 4 mg, 1 or 2 times a day. Nasal solution: 1 to 2 sprays per day. Tablets: 0.1 to 0.8 mg, 2 times a day in divided doses. For bedwetting in patients age 6 and over-- Tablets: 0.2 mg at bedtime. May be increased to 0.6 mg. For von Willebrand's type 1-- Injection: 0.3 mg per 2.2 lbs (1 kg) of body weight per day, administered over 15 to 30 minutes. Lowest effective dose will be determined by the doctor based on the patient's response to the drug."
http://www.wholehealthmd.com/refshelf/drugs_view/1,1524,179,00.html
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