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Cholestyramine Therapy for Dyslipidemia in Non-Insulin-dependent Diabetes Mellitus, Annals of Internal Medicine:"To assess clinical efficacy and tolerability of cholestyramine therapy in patients with dyslipidemia and non-insulin-dependent diabetes mellitus (NIDDM).
Design: A randomized, double-blind, crossover study of cholestyramine (8 g twice daily) compared with placebo for a period of 6 weeks each."
http://www.acponline.org/journals/annals/15sep94/therapy.htm
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What You Need To Know About Cholestyramine, Cleveland Clinic:"Cholestyramine is prescribed, along with dietary changes (restriction of cholesterol and fat intake), to reduce low density lipoprotein (LDL) and total cholesterol. LDL is a lipid (fats) found in your blood and is also called "bad or lousy cholesterol." Cholestyramine is used to lower these blood levels."
http://www.clevelandclinic.org/health/health-info/docs/0600/0671.asp?index=4797
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Cholestyramine (Oral), Drugs and Foods to Avoid, Genesis Health System:"Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products
Make sure your doctor knows if you are taking Coumadin®.
Cholestyramine may change the way many other medicines work. Take other medicines 1 hour before or 4 to 6 hours after you take cholestyramine.
Talk with your doctor or pharmacist if you need help deciding the best time to take your medicines."
http://www.genesishealth.com/micromedex/quickdrug/dnx0186.aspx
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Cholestryamine, (Questran), HealthSquare:" A lot of attention is given to many of the miracle drugs offered by modern science. Equally impressive are some of the diagnostic tools that have been developed to detect heart disease, so that it can be appropriately treated and controlled. Diagnostic procedures range from non invasive tests done outside the body to invasive probes into the circulatory system. Often, positive findings on non invasive tests like the electrocardiogram or treadmill test signal the need for more invasive procedures. Electrocardiogram: The electrocardiogram (known popularly as the ECG or EKG) is a graphic representation of the electrical currents that run through the heart as it pumps. The ECG can be taken while you are resting or exercising (usually on a treadmill), and the only discomfort you might experience is several small electrodes attached to your skin. Normal ECG readings in women during exercise are likely to mean that no heart disease is present; and compared
with men abnormal readings are much more likely to be false positives; that is, not truly a sign of heart disease. One study found false positives in only 8 percent of the men tested and a whopping 67 percent of women undergoing the same test. In other words, even if stress testing is positive, there's still an excellent chance that your heart is healthy. Some doctors skip the stress test altogether, especially in a patient with clear physical symptoms (such as repeated incidents of angina), and move directly to more specific testing."
http://www.healthsquare.com/fgwh/wh1ch12c.htm
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Cholestryamine, (Questran), ImmuneSupport.com:"Dr. Paul Cheney on "Chronic Neurotoxin" Protocol for Chronic Fatigue Syndrome: Questran/Cholestryamine by Carol Sieverling, ImmuneSupport.com, 02-06-2002. Author's Note: The following is based on notes taken during a recent conversation with Dr. Cheney. He has not edited or reviewed this information. Reprinted with permission of Carol Sieverling. Bottom line: Cheney is going to incorporate the test and a modified version of the treatment described below into his practice. The book "Desperation Medicine", and the website where it can be ordered (www.chronicneurotoxins.com), contain intriguing information about a test and a treatment to detect and remove neurotoxins being generated within our bodies. The toxins end up in the brain (thus "neurotoxins) and other organs of the body. The test, used by the toxicology division of the Environmental Protection Agency, is simple, inexpensive, quick, and non-intrusive - you just look at a card with a series of
lines of varying shades of gray and indicate whether they are vertical, left-leaning, or right-leaning. It's the visual equivalent of a hearing test, detecting what frequencies you can and cannot perceive. It's called a VCS test: visual contrast sensitivity test. Sometimes it's also called FACT: functional acuity contrast test. Cheney talked at length to the company that makes it, Stereo Optical Co. (1-800-344-9500). The test equipment costs $275. Doctors typically charge about $25 for the test. Cheney explained that trouble perceiving mid-range frequencies indicates the sub-cortical/deep brain injury typical of CFS, problems perceiving low frequencies indicate cortical injuries such as Alzheimer's, and problems perceiving high frequencies indicate injury to the retina or optic nerve. These visual problems are very subtle and not at all apparent apart from the test. Cheney found it to be a very intriguing test, has ordered it, and will be incorporating it into the tests given at his clinic. The treatment recommended in the book and website is 4 scoops daily of Questran (cholestyramine) on an empty stomach, an old cholesterol drug. It is not actually absorbed - it never enters the system. It stays in the gut, binding and then eliminating fat-soluble toxins that otherwise are reabsorbed and circulate repeatedly throughout the body. (Lyme patients are given pioglitazone/Actos to minimize the terrible herx - this drug makes CFS patients worse.) After much investigation and a long conversation with the book's author, Cheney believes that this may be a helpful tool in the treatment of CFIDS. However, he will implement the protocol somewhat differently. Cheney feels that, like any aggressive detox agent, it could mobilize too many toxins too quickly. He is going to be using much lower doses. "Start low and build slowly," is what he said. Another change in the protocol occurred when Cheney learned that Questran contains 1 tsp of pure sugar per scoop. Taking a total of 4 teaspoons of sugar a day on an empty
stomach per the original protocol could cause or aggravate gut dysbiosis - overgrowth of harmful bacteria and fungi. Most of us know that sugar feeds the candida and other things many of us have! There is a Questran Light, but it contains aspartame. Not a good option. Cheney talked to Bristol Myers, the manufacturer of Questran, and believes that while not widely used or available, it is possible to get raw Questran without sugar or aspartame. Having patients add stevia to it to sweeten it safely was mentioned."
http://www.immunesupport.com/library/cfstreatment.cfm/ID/3326
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Questran, What is it used for? Jackson Gastroenterology:"This medication is used to treat the itching that occurs with certain types of liver disease. Itching occurs because of retention of bile salts which are made by the liver. Cholestyramine binds these bile salts in the intestinal tract, thereby reducing them in the blood and relieving the itching that elevated bile salts can cause. Diarrhea occurs in some people after they have had their gallbladder removed or after an operation where the lower small bowel (ileum) is removed, as in Crohn's disease. In these circumstances, bile reaches the colon unimpeded and acts like a laxative, causing diarrhea. Cholestyramine absorbs and binds these bile salts, helping to improve the diarrhea problem. Cholestyramine is also used to lower the cholesterol level and to bind up various toxins or poisons that may have been ingested."
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Cholestyramine (Oral), Description, Medline Plus:"Cholestyramine is used to lower high cholesterol levels in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels. Cholestyramine is also used to remove substances called bile acids from your body. With some liver problems, there is too much bile acid in your body and this can cause severe itching.
Cholestyramine works by attaching to certain substances in the intestine. Since cholestyramine is not absorbed into the body, these substances also pass out of the body without being absorbed."
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Cholestyramine, Indications, RXlist.com:"Cholestyramine for Oral Suspension, USP powder is indicated as adjunctive therapy to diet for the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia (elevated low density lipoprotein [LDL] cholesterol) who do not respond adequately to diet. Cholestyramine for Oral Suspension, USP powder may be useful to lower LDL cholesterol in patients who also have hypertriglyceridemia, but it is not indicated where hypertriglyceridemia is the abnormality of most concern."
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Cholestyramine, Why Prescribed, WholehealthMD:"Why Prescribed
To reduce cholesterol in people with high blood levels of low-density lipoprotein (LDL), as part of a comprehensive treatment program that includes exercise and special diet. The drug is also used to relieve itching caused by high levels of bile acids in the blood, a problem associated with blockage of the bile ducts. Cholestyramine may also be used to prevent some types of diarrhea or to serve as an antidote to poisoning from or overdose of digitalis drugs."
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Cholestryamine, (Questran), Yahoo! Inc.:"Why is this drug prescribed? Questran is used to lower cholesterol levels in the blood of people with primary hypercholesterolemia (too much LDL cholesterol). Hypercholesterolemia is a genetic condition characterized by a lack of the LDL receptors that remove cholesterol from the bloodstream. This drug can be used to lower cholesterol levels in people who also have hypertriglyceridemia, a condition in which an excess of fat is stored in the body. This drug may also be prescribed to relieve itching associated with gallbladder obstruction. It is available in two forms: Questran and Questran Light. The same instructions apply to both."
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