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EPOPROSTENOL SODIUM, Indications, Drugs.com:"Hypertension, pulmonary (treatment)—Epoprostenol is indicated for the long-term intravenous treatment of primary pulmonary hypertension (PPH) in patients with New York Heart Association (NYHA) Class III and Class IV heart failure . Epoprostenol should be used only by clinicians experienced in the diagnosis and treatment of PPH ."
http://www.drugs.com/xq/cfm/pageID_0/htm_003428/type_pros/bn_Epoprostenol%20Sodium/micrpro_medex/qx/index.htm
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Flolan, Overview of Flolan Treatment, Flolan Information Center:"Flolan or epoprostenol is a form of a naturally occurring molecule in our bodies called prostaglandin. Doctors use prostaglandin to treat patients with Primary Pulmonary Hypertension (PPH). Flolan is helping many severely ill patients who do not respond to treatment with calcium channel blockers such as Nifedipine."
http://www.flolan-center.com/pages/flolan_effective.html
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Epoprstenol, Drug improves survival in lung disorder, Health and Age:"The drug epoprostenol increases survival in pulmonary hypertension by up to 80 per cent.
Primary pulmonary hypertension (PPH) is a rare disorder in which the blood pressure in the arteries serving the lungs rises dramatically. The heart's right ventricle is forced to work far harder to pump blood and the condition is linked with a high mortality rate."
http://www.healthandage.com/Home/gm=20!gsq=epoprostenol!gid1=2054
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Epoprostenol Sodium, Action, Massachusetts General Hospital:"Prostaglandin with anti-proliferative and vasodilatory properties."
http://www.mgh.harvard.edu/pharmacy/ICU%20Guidelines/epoprostenol.htm
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Epoprostenol (Systemic), Description, MEDLINEplus:"Epoprostenol (e-poe-PROST-en-ole) belongs to a group of agents called prostaglandins. Prostaglandins occur naturally in the body and are involved in many biological functions. Epoprostenol is used to treat the symptoms of primary pulmonary hypertension, or the high blood pressure that occurs in the main artery that carries blood from the right side of the heart (the ventricle) to the lungs. When the smaller blood vessels in the lungs become more resistant to blood flow, the right ventricle must work harder to pump enough blood through the lungs. Epoprostenol works by relaxing blood vessels and increasing the supply of blood to the lungs, reducing the workload of the heart."
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203429.html
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Epoprostenol sodium, Uses, Nurses PDR:"Long-term IV treatment of primary pulmonary hypertension in New York Heart Association Class III and Class IV clients."
http://www.nursespdr.com
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Flolan, What is it, PHCentral:"Flolan is a form of prostacyclin. It was approved by the FDA in 1995, and is produced by Glaxo Wellcome, Inc. It is a potent vasodilator that relaxes the blood vessels in the lungs and slows the process of scarring and cell growth within the lung’s blood vessels, which prevents further narrowing. It also assists in increasing cardiac output and oxygen saturation. "
http://www.phcentral.org/medical/treatments/flolan.html
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EPOPROSTENOL, ProactiveHealth.com:"Treats the symptoms of pulmonary hypertension, a lung disorder that increases blood pressure in the main artery that carries blood from the heart to the lungs."
http://www.proactivehealth.com/Drug/DrugData.asp?ID=809
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Epoprostenol sodium, Indications, RXlist:"FLOLAN is indicated for the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy."
http://www.rxlist.com/cgi/generic/flolan_ids.htm
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FLOLAN®, Action And Clinical Pharmacology, RxMed.com:"Epoprostenol, also known as prostacyclin, PGl2 or PGX, a metabolite of arachidonic acid, is a naturally occurring prostaglandin. Epoprostenol has two major pharmacological actions: (1) direct vasodilation of pulmonary and systemic arterial vascular beds, and (2) inhibition of platelet aggregation. In animals, the vasodilatory effects of epoprostenol reduce right and left ventricular afterload and increase cardiac output and stroke volume."
http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20F)/FLOLAN.html
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