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Ardeparin Sodium, Centaxarin®:"Since unfractionated heparin first came into clinical use, there has been a demand for a more selective and more convenient antithrombotic agent. Some progress was made, e.g. low dose heparin (1), but until recently no major advance had been achieved."
http://heparin.com/ardeparin.html
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Ardeparin Sodium, Heparin.com:"The half-life of ardeparin is twice that of unfractionated heparin and is less dose-dependent. One mg of protamine sulfate neutralizes approximately 100 anti-Factor Xa Units of administered ardeparin. The effect on APTT is almost immediately and completely neutralized. The effect on anti-Factor Xa is antagonized by 78%, based on AUC evaluation."
http://www.heparin.com/heparin_fragments.html
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Ardeparin, Blueprint For Health.com:"Ardeparin is an anticoagulant (blood thinner). Ardeparin prevents the formation of blood clots.
Ardeparin is used to prevent blood clot formation following knee replacement surgery.
Ardeparin may also be used for purposes other than those listed in this medication guide."
http://blueprint.bluecrossmn.com/topic/topic100588463
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ardeparin sodium sc solution:"This medicine is an antithrombotic agent used to prevent the formation of harmful blood clots, especially after knee replacement surgery. It may also be used for other conditions as determined by your doctor."
http://www.healthtouch.com/bin/medshow.asp?fname=/level1/pde/pde7451.htm&title=ardeparin+sodium+sc+solution
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Ardeparin, Brand Name: Normiflo, MywebMD.com:"Important Information Description Who should not take it? How should I take it? What happens if I miss a dose? What happens if I overdose? What should I avoid while taking it? What are the side effects? What other drugs will affect it? Where can I get more information?"
http://my.webmd.com/drug_article/article/4046.1438?bn=Ardeparin
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Ardeparin (Systemic), Medline Plus:"Ardeparin (ar-dee-PA-rin) is used to prevent deep venous thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism. Ardeparin is used for several days after knee replacement surgery, while you are unable to walk. It is during this time that blood clots are most likely to form. Ardeparin also may be used for other conditions as determined by your doctor."
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203494.html
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Ardeparin sodium (Normiflo), Side Effects, Nurses PDR:"Bleeding events: Intraoperative bleeding, postoperative surgical site or nonsurgical site hematoma or hemorrhage, bleeding requiring an invasive procedure; ecchymosis, GI hemorrhage hematemesis, hematuria, melena, petechiae, rectal hemorrhage, retroperitoneal hemorrhage, CVA abnormal stools. GI: N&V, constipation. Allergic reaction: Maculopapular rash, vesiculobullous rash, urticaria. CNS: Confusion, dizziness, headache, insomnia. Miscellaneous: Fever, pruritus, anemia, thrombocytopenia, arthralgia, chest pain, dyspnea, reactions at injection site (edema, hypersensitivity, inflammation, pain), peripheral edema."
http://www.nursespdr.com/members/database/ndrhtml/ardeparinsodium.html
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Ardeparin sodium, qxhealth.com:"The results of expanded toxicological studies comprising acute -, chronic -, and reproduction toxicity, local tolerance, and safety pharmacology justifying the use of ardeparin sodium in human phase I trials by intravenous and subcutaneous routes.Ardeparin sodium is rapidly and almost completely absorbed from the subcutaneous depot. Data from clinical studies have shown that the pharmacodynamic activity of ardeparin declines at a slower rate than that of unfractionated heparin. In addition, the bioavailability of ardeparin sodium is greater than that of unfractionated heparin following subcutaneous administration. Ardeparin sodium is absorbed from the subcutaneous depot to a much greater extent; 80 to 90% compared to 10 to 20% for unfractionated heparin. "
http://www.qxhealth.com/licensing/cfml/Details.cfm?sum_ID=20
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Ardeparin, Medical Advisor 2001, Possible Drug Interactions:"When you take this medicine with other medicines, it may increase or decrease the effects of the medicines. Or the combination may cause harmful side effects. Some medicines that may interact with this medicine are:
aspirin and other salicylates
clopidogrel (Plavix)
dipyridamole (Persantine)
nonsteroidal anti-inflammatory drugs such as ibuprofen (Advil, Motrin, Nuprin), naproxen (Naprosyn, Aleve), and ketoprofen (Orudis).
sulfinpyrazone (Anturane)
ticlopidine (Ticlid)
warfarin (Coumadin)."
http://www.realage.com/Connect/healthadvisor/medication/ma/ardepari.htm
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Ardeparin, Skidmore's Nursing Drug Updates, Contraindications:"Hypersensitivity to this drug, pork products, heparin, or other anticoagulants; hemophilia, leukemia with bleeding, thrombocytopenic purpura, cerebrovascular hemorrhage, cerebral aneurysm, severe hypertension, other severe cardiac disease."
http://www.us.elsevierhealth.com/MERLIN/nursingdrugupdates/Skidmore/archive/ardeparin.html
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Ardeparin Sodium for Extended Out-of-Hospital Prophylaxis against Venous Thromboembolism after Total Hip or Knee Replacement, Annals of Internal Medicine:"Among patients who had total knee or total hip replacement and received 4 to 10 days of postoperative ardeparin prophylaxis, the cumulative incidence of symptomatic venous thromboembolism or death after hospital discharge was not significantly reduced by extended out-of-hospital ardeparin prophylaxis. Extended ardeparin use could provide a maximum 2.2–percentage point true reduction in such events. The benefit of extended ardeparin use is not clinically important for most patients. Future research should identify high-risk patients who would benefit most from extended prophylaxis."
http://www.annals.org/issues/v132n11/abs/200006060-00002.html
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Created on July 24, 1999
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