Nursing & Healthcare Directories on: The Nursefriendly
Prescription Drugs, Medications
Sulfa Drugs, Sulfonamide Antibiotics,
Sulfadiazine, Microsulfon

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Sulfadiazine, Drug Description, The Access Project:"Sulfadiazine is a sulfa drug used in combination with pyrimethamine and leucovorin as maintenance treatment to prevent recurrence of toxoplasmosis. When the immune system becomes weak - typically when a person has below 100 T4 cells - toxoplasmosis becomes active and causes disease."
http://www.atdn.org/access/drugs/sulf.html

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Sulfadiazine, Update: Availability of Sulfadiazine -- United States, February 12, 1993, Center for Disease Control and Prevention:"Sulfadiazine is a sulfa drug commonly used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome (AIDS) and newborns with congenital infections. In December 1992, CDC reported that the domestic manufacturer of sulfadiazine had ceased production in October 1992 and that no large inventories of the drug were available from major distributors (1). On February 8, CDC obtained permission from the Food and Drug Administration (FDA) to proceed with an "Investigational New Drug" (IND) application protocol under which sulfadiazine may be imported and made available to physicians until a domestic commercial source is re-established."
http://www.cdc.gov/epo/mmwr/preview/mmwrhtml/00019581.htm

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Sulfadiazine, Meningococcal meningitis: prophylactic sulfadiazine reduced spread, Journal of the American Medical Association 1943:"Soldiers at risk of meningococcal meningitis who receive prophylactic sulfadiazine compared with no treatment were less likely to develop the disease (NNT = 500 at 8 weeks) ."
http://www.eboncall.co.uk/CATs/meningitis_Kuhns_43.htm

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Sulfadiazine, Indications, Web Health Center:" Sulphadiazines are used to treat infections and are effective against : E.coli, Klebsiella, Enterobacter, Proteus mirablis, Proteus.vulgaris, Staph.aureus, Toxoplasma, H.influenzae.It can also be used in prevention of rheumatic fever, chancroid, trachoma, inclusion conjuctivitis and nocardiosis."
http://www.webhealthcentre.com/ref/drugix/di0129.asp

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Sulfadiazine, Why is this drug prescribed, Toronto General Hospital:"Sulfadiazine is an antibiotic which is a member of the sulfonamides or sulfa drugs. Sulfadiazine is used to treat a variety of infections, including Toxoplasmosis, an infection of the brain. It can also be used to prevent certain types of meningococcal disease (i.e., meningitis) when the organism is known to be sensitive to sulfonamides."
http://www.tthhivclinic.com/sulfad.htm

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Sulfadiazine, Sulfadiazine-induced Crystalluria and Renal Failure in a Patient With AIDS, 1999, American Board of Family Practice:"Cerebral toxoplasmosis is one of the most treatable opportunistic infections of the central nervous system in patients with the acquired immunodeficiency syndrome (AIDS).[1,2] A combination of sulfadiazine and pyrimethamine is the therapy of choice, producing a favorable clinical response in 68 to 95 percent of patients receiving this regimen."
http://www.familypractice.com/journal/abfpjournal_frame.htm?main=/journal/1999/v12.n03/1203.09/art-1203.09.htm

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Sulfadiazine(Coptin), How does this medication work, MediResource:"This medication is used to treat infections of the urinary tract that are caused by certain types of bacteria. It works by blocking important steps in the metabolism of the bacteria."
http://www.mediresource.com/pages/DrugInfo.asp?BrandNameID=726

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Sulfadiazine, How is toxoplasmosis treated, AIDS Info Net:"Toxo is treated with a combination of pyrimethamine (DaraprimŽ) and sulfadiazine. Both drugs can cross the blood-brain barrier. The toxoplasma protozoa needs vitamin B to live. Pyrimethamine stops toxo from getting vitamin B. Sulfadiazine prevents toxo from using it. The normal dosage of these drugs is 50 to 75mg of pyrimethamine with 2 to 4 grams per day of sulfadiazine. These drugs both interfere with vitamin B and can cause anemia. People with toxo usually take Leucovorin, a form of folic acid (a B vitamin), to prevent anemia. This combination of drugs is very effective against toxo. Over 80% of people show improvement within 2 to 3 weeks. Toxo usually comes back after the first episode. People who have had toxo should keep taking the anti-toxo drugs at a lower, maintenance dose."
http://www.aidsinfonet.org/517-toxo.html#anchor50142

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Sulfadiazine, Side Effects, Johs Hopkins:": Hypersensitivity with rash, drug fever, serum-sickness, urticaria; crystalluria reduced with adequate urine volume (1,500 mL/day) and alkaline urine - use with care in renal failure; marrow suppression - anemia, thrombocytopenia, leukopenia, hemolytic anemia due to G6-PD deficiency."
http://www.hopkins-aids.edu/publications/book/ch6_sulfadiazine.html

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Sulfadiazine, Who is this for, Drug Digest:"Sulfadiazine, a "sulfa" drug, eliminates bacteria that cause infections, especially urinary tract infections. Antibiotics will not work for colds, flu, or other viral infections."
http://www.drugdigest.org/DD/DVH/Uses/0,3915,763%7CSulfadiazine,00.html

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Healthcare You Can Afford! Discover real savings! Save up to 50% on healthcare, up to 30% on Alternative & Chiropractic, and from 15% to 40% on Prescriptions. Savings on Dental and Vision. All pre-existing conditions accepted. Not Insurance. For information call Andrew Lopez, RN (856-415-9617) CEO8257
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Last updated by Andrew Lopez, RN March 3, 2005
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