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Streptomycin Sulfate, Uses, Nurses PDR:"With other drugs to treat Mycobacterium tuberculosis infections. Used in the following infections when less potentially hazardous drugs are either ineffective or contraindicated. UTIs due to Escherichia coli, Proteus, Enterobacter aerogenes, Klebsiella pneumoniae and Enterococcus faecalis. With penicillin to treat endocardial infections due to Streptoccus viridans and E. faecalis. With other drugs to treat bacteremia. With another agent to treat respiratory, endocardial, and meningeal infections due to H. influenzae. Infections due to Brucella Haemophilus ducreyi (chancroid), Francisella tularensis (tularemia), Pasturella pestis (plague), and granuloma inguinale. Investigational: As part of multiple-drug regimen to treat Mycobacterium avium complex in AIDS clients."
http://www.nursespdr.com/members/database/archives/streptomycinsulfate.html
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Streptomycin, Encyclopedia, Fact Monster:"streptomycin , antibiotic produced by soil bacteria of the genus Streptomyces and active against both gram-positive and gram-negative bacteria (see Gram's stain ), including species resistant to other antibiotics, e.g., some streptococci, penicillin-resistant staphylococci, and bacteria of the genera Proteus and Pseudomonas. Originally isolated by Selman A. Waksman and Albert Schatz in 1947, streptomycin is effective against tubercle bacilli and is a mainstay of tuberculosis therapy."
http://www.factmonster.com/ce6/sci/A0846951.html
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Streptomycin, Anti-infectives, Drug Monitor:"Streptomycin (Mol wt = 1457.41) was the first of the aminoglycoside antibiotics (AGs) developed. It was isolated more than 50 years ago and was initially used to treat pulmonary tuberculosis. Streptomycin is also highly active against gram-negative aerobic pathogens with some activity against gram-positive cocci. Streptomycin use has fallen out of favor due to widespread use of other AGs including gentamicin and tobramycin. Widespread resistance of Enterobacteriaceae has also restricted the use of streptomycin to a few specific clinical situations."
http://www.home.eznet.net/~webtent/streptomycin.html
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Streptomycin, Dosage, The Access Project:"Streptomycin is given by intramuscular injection. Adults are given 1 g daily in combination with 5 g of PAS and 200-300 mg of isoniazid. Ultimately the streptomycin should be stopped or reduced to 1 g two to three times weekly."
http://www.aegis.com/factshts/network/access/drugs/stre.html
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Streptomycin, Columbia Encyclopedia, Bartleby.com:"Because streptomycin-resistant tubercle bacilli emerge during treatment, the antibiotic is usually used in combination with one or more of the drugs isoniazid, ethambutol, and aminosalicylic acid. Streptomycin acts by inhibiting protein synthesis and damaging cell membranes in susceptible microorganisms. Possible side effects include injury to the kidneys and nerve damage that can result in dizziness and deafness."
http://www.bartleby.com/65/st/streptom.html
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Streptomycin, Post Herpetic Neuralgia: Use of streptomycin, TelMedPak.com:"We have found initial results with streptomycin encouraging and worthy of further investigation. The diversity of action of streptomycin on the cellular mechanism makes it difficult to predict the result. It is, therefore, desirable to conduct more formal and controlled trials on the effects of streptomycin in neurogenic pain. It is worthwhile to use streptomycin with a local anaesthetic in post-herpetic neuralgia."
http://www.telmedpak.com/homes.asp?a=pain_clinic&b=pn
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Streptomycin, Actinobacteria, xReferences:"A phylum of Gram-positive mostly anaerobic nonmotile bacteria. Many species are fungus-like, with filamentous cells producing reproductive spores on aerial branches similar to the spores of certain moulds. The phylum includes bacteria of the genera Actinomyces, some species of which cause disease in animals and man; and Streptomyces, which are a source of many important antibiotics (including streptomycin)."
http://www.xrefer.com/entry.jsp?xrefid=485116
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Streptomycin, Pharmacokinetics, Web Health Center:"
Streptomycin is poorly absorbed from GIT hence administered intramuscularly. It reaches a peak concentration in 1/2 to1 hour. It is mainly concentrated in the liver, kidneys and in skeletal muscles. It is excreted mainly in the unchanged form via urine and a part is metabolised in the liver."
http://www.webhealthcentre.com/ref/drugix/di0128.asp
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Streptomycin, Clinical Pharmacology, RXlist:"Appreciable concentrations are found in all organ tissues except the brain. Significant amounts have been found in pleural fluid and tuberculous cavities. Streptomycin passes through the placenta with serum levels in the cord blood similar to maternal levels. Small amounts are excreted in milk, saliva, and sweat."
http://www.rxlist.com/cgi/generic2/streptomycin_cp.htm
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