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Aminoglycoside Antibiotics
Gentamicin Sulfate, Garamycin

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Gentamycin, Description, AG Scientific:"Broad spectrum, cell culture antibiotic that is non toxic to viruses and mammalian cells at antibacterial levels. It is useful for long-term virus and tissue culture studies. Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit."
http://www.agscientific.com/Item/G1067.htm

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Gentamycin, Indications, Web Health Centre:"It is active against some gram positive and many gram negative organisms like E.Coli, Enterobacter, Klebsiella, Proteus, Pseudomonas, Citrobacter, Staph. Epidermidis, and Listeria Monocytogenes and Campylobacter."
http://www.webhealthcentre.com/ref/drugix/DI0066.asp

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Gentamycin, Functioning, Bhratnet.com:"Gentamycin is not well absorbed by oral route, hence it is usually given parentrally. After IM injection it reaches a peak level in 60 to 90 mins. It is bound to plasma proteins and is excreted unchanged by glomerular filtration via the kidneys."
http://www.bharatnet.com/health/medicine/all_files/gentamycin.htm

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Gentamycin, Side Effects, Electronic Doctor:"Most nephrotoxic of all aminoglycosides. Demonstrated by the presence of protein in the urine, increased BUN, NPN, serum creatinine and oligouria. CNS: Numbness, skin tingling, muscle twitching, convulsions. Adverse effects on both vestibular and auditory branches of the eighth cranial nerve have been reported (ototoxicity). INCREASED RISK WITH: Patients with renal impairment. High doses or prolonged use. Concomitant use with other nephrotoxic drugs. Previous history of eighth cranial nerve damage. OTHER: Rash, urticaria, headache, increased/decreased reticulocyte count, granulocytopenia, convulsions, anaemia, purpura, increased serum bilirubin and increased serum transaminases (SGOT,SGPT)."
http://www.edoc.co.za/medilink/actives/464.html

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Gentamycin, How prevalent is nephrotoxicity in Gentamycin therapy, November 11, 1998, Seminars in Nephrology:"Aminoglycoside antibiotics maintain a leading role in antibacterial therapy of severe gram-negative infections despite nephrotoxicity complicating 10% to 20% of therapeutic courses. Risk factors for aminoglycoside-induced renal injury have been identified."
http://www.emory.edu/WHSCL/grady/amreport/litsrch98/p981111a.html

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Gentamicin, Dear Customer/Health Professional, November 30, 1998, United States Food and Drug Administration:" American Pharmaceutical Partners, Inc. is voluntarily withdrawing all unexpired 40mg/mL lots of the Gentamicin Sulfate Injection, USP. These lots were manufactured by Fujisawa USA, Inc. and by American Pharmaceutical Partners, Inc. and distributed under the Fujisawa Inc. label. A list of product codes, lot numbers, NDC numbers and expiration dates is attached. The reason for this voluntary withdrawal is an increase in the frequency of reports of adverse reactions to the 40 mg/mL products. The vast majority of reported reactions, where dosing information is available, have been associated with the administration of once-daily dosages of the product."
http://www.fda.gov/medwatch/safety/1998/gentam.htm

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Gentamicin, Safetychecker, General Nutrition Center:"Gentamicin is an aminoglycoside antibiotic <../Drug/Antibiotics.htm> used to treat infections <../Concern/Infection.htm> caused by many different types of bacteria. Gentamicin is usually administered by intravenous (IV) infusion or intramuscular injection. There are special gentamicin-containing drug products to treat eye and skin infections."
http://www.gnc.com/health_notes/Drug/Gentamicin.htm

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Gentamicin, Interactions, Healthwell:"Gentamicin has been associated with hypocalcemia (low calcium levels) in humans.1 In a study using rats, authors reported oral calcium supplementation reduced gentamicin-induced kidney damage.2 The implications of this report for humans are unclear. People receiving gentamicin should ask their doctor about monitoring calcium levels and calcium supplementation."
http://www.healthwell.com/healthnotes/Drug/Gentamicin.cfm

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Gentamicin, A Trial of Ciprofloxacin and Metronidazole vs Gentamicin and Metronidazole for Penetrating Abdominal Trauma, December 1998, Archives of Surgery:"Ciprofloxacin and gentamicin, each in combination with metronidazole, were equivalent in their ability to prevent infections after penetrating abdominal trauma; other factors, especially the receipt of blood transfusions, had much more effect on the incidence of infection. Infection greatly increases the length of hospital stay and hospital charges. The use of an increased dosing regimen of 2.5 mg/kg every 12 hours of gentamicin sulfate was effective at obtaining a therapeutic peak serum concentration."
http://archsurg.ama-assn.org/issues/v133n12/abs/ssi8040.html

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Gentamicin Sodium, Pharmacology, Kuddly Korner 4 U:"A bactericidal aminoglycoside with action primarily against gram negative aerobes. It is widely distributed in extracellular fluid and does not readily cross the blood-brain barrier. The drug tends to accumulate in the kidneys and the inner ear, explaining the reason for nephro and ototoxicity. Gentamicin, as with other aminoglycosides, should be used with caution in existing renal conditions or neuromuscular disease. The drug is not intended for long term use."
http://www.kuddlykorner4u.com/Gentamicin.html

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