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Peniciclovir (Denavir) absorption and distribution:micromedex:"Famciclovir is absorbed in the upper intestine and rapidly converted in the intestinal wall to the active compound, penciclovir {09}. The bioavailability of peniciclovir after oral administration of famciclovir is approximately 77% {01} {09}. Famciclovir may be taken without regard to meals; although a decrease in the time to peak serum concentration and peak serum concentration of penciclovir was seen when famciclovir was taken with food or after a meal, there was no decrease in the extent of systemic availability {01} {03}. The steady-state volume of distribution of penciclovir is approximately 1 liter per kilogram (L/kg) {01}."
http://www.micromedex.com/products/demos/webready/professional/usp_di/data_004.html
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Peniciclovir (Denavir) general information from the makers of this drug:Novartis Pharmaceuticals Corporation:"DenavirŽ was generally well tolerated in all clinical trials -- the most frequently reported adverse events with DenavirŽ and placebo in the pivotal trials, respectively, were headache (5.3% vs 5.8%) and application site reaction (1.3% vs 1.8%). In the most recent trial the adverse events were no different."
http://www.denavir.com/html/index-about.htm
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Peniciclovir (Denavir) as a treatment for shingles:shingles.com:"For many people age 50 or older, prescription oral FAMVIR may significantly shorten the duration of PHN, reducing the number of days you have pain. In one clinical study, people age 50 or older who took FAMVIR experienced PHN for about 63 days compared with 163 days for people who did not take FAMVIR. The people who took FAMVIR started taking the medication within 72 hours (3 days) after the shingles rash appeared. FAMVIR is available in easy-to-swallow tablets. In patients with shingles, the recommended dose of FAMVIR is 500 mg, 3 times a day, for 7 days. If you have kidney problems, your doctor will determine if FAMVIR is appropriate and if so, what the right dose is for you. FAMVIR is a prescription oral medication that is available in easy-to-swallow tablets"
http://www.shingles.com/info/treating/diagnosis/treatment.jsp
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Peniciclovir (Denavir) for the treatment of herpesviruses:stanford.edu:"In randomized, double-blind, placebo-controlled, patient-initiated trials of DenavirŠ, the penciclovir-treated patients has shorter lesion-healing times, reduced symptoms, and shorter periods of viral shedding. Patients treated early and late in their episode had equivalent outcomes. Also from these studies came the hypothesis that penciclovir may keep lesions from becoming severe and therefore prevent severe attacks. Because of these positive effects, DenavirŠ became the first treatment for episodic use of herpes labialis in the United States. For therapy of HSV-1 and HSV-2 in immunocompromised patients, penciclovir is equal in efficacy to acyclovir, but can be administered less frequently because of its extended half-life in the cell."
http://www.stanford.edu/group/virus/herpes/2000/herpes2000drug2.html
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Possible side effects of Peniciclovir (Denavir):U.S. National Library of Medicine,:"Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur: Rare Mild pain, burning, or stinging Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome: More common Headache Less common Change in sense of taste; decreased sensitivity of skin, particularly to touch; redness of the skin; skin rash Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor."
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203495.html#SXX25
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Precautions while taking Peniciclovir (Denavir):rxlist:"Denavir should only be used on herpes labialis on the lips and face. Because no data are available, application to human mucous membranes is not recommended. Particular care should be taken to avoid application in or near the eyes since it may cause irritation. The effect of Denavir has not been established in immunocompromised patients. Carcinogenesis, Mutagenesis, Impairment of Fertility In clinical trials, systemic drug exposure following the topical administration of penciclovir cream was negligible, as the penciclovir content of all plasma and urine samples was below the limit of assay detection (0.1 mcg/mL and 10 mcg/mL, respectively). However, for the purpose of inter-species dose comparisons presented in the following sections, an assumption of 100% absorption of penciclovir from the topically applied product has been used. Based on use of the maximal recommended topical dose of penciclovir of 0.05 mg/kg/day and an assumption of 100% absorption the maximum theoretical plasma AUC0-24 hrs for penciclovir is approximately 0.129 mcg.hr/mL."
http://www.rxlist.com/cgi/generic3/penciclovir_wcp.htm
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Peniciclovir (Denavir) special information if you are pregnant or breastfeeding:gettingwell.com:"The effects of Denavir during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Researchers do not know whether this drug will appear in breast milk after external application. For safety's sake, your doctor may advise you to discontinue breastfeeding your baby until your treatment with Denavir is finished. You should begin applying Denavir at the first hint of a developing cold sore. The drug will not cure herpes, but it will reduce pain and may speed healing."
http://www.gettingwell.com/drug_info/rxdrugprofiles/drugs/DEN1123.shtml
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How to use and store Peniciclovir (Denavir)::"Your doctor will tell you how much medicine to use and how often. Use this medicine on the sores on your lips or face. It should not be used in your mouth. Do not put the medicine in or near your eyes. Wash your hands with soap and water before and after using this medicine. Start using the medicine at the first sign of a cold sore (tingling, swelling, or itching). Your doctor may tell you to use enough of the cream to cover the cold sores, every 2 hours (while you are awake)for 4 days. Store the cream at room temperature away from heat, moisture, and direct light. Do not freeze. Keep all medicine out of the reach of children."
http://health.yahoo.com/health/drugs/0794/0.html
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Healthcare You Can Afford!
Discover real savings! Save up to 50% on healthcare, up to 30% on Alternative & Chiropractic, and from 15% to 40% on Prescriptions. Savings on Dental and Vision. All pre-existing conditions accepted. Not Insurance. For information call Andrew Lopez, RN (856-415-9617) CEO8257
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