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Lopinavir, (Kaletra), AIDSmeds.com:"The liquid formula of Kaletra contains alcohol. You should talk to your doctor if you are taking, or plan to take, metronidazole (Flagyl) or disulfiram, since severe nausea and vomiting can occur. If you are taking both ddI (Videx) and Kaletra, ddI should be taken one hour before or two hours after Kaletra. Follow your doctor's instructions with respect to high-risk activities such as unprotected sex and the sharing of needles. Kaletra is not a cure for HIV or AIDS, and you can still transmit the virus to others during therapy with this medication."
http://www.aidsmeds.com/drugs/Kaletra.htm

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Lopinavir, (Kaletra)The AIDS Treatment Data Network:"Trial results: Kaletra has shown a strong anti-HIV effect in clinical trials. One study investigated different doses of Kaletra taken with d4T (Zerit) and 3TC (Epivir). No one in this study had taken anti-HIV drugs before. After 72 weeks (nearly a year and a half) of treatment, 80% of the 51 people taking the approved dose of Kaletra had viral load levels less than 400 copies. T-cells increased by an average of 256 cells. About 4% (1 in 25) of the participants dropped out of the study because of side effects."
http://www.aegis.com/factshts/network/simple/lopi.html

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Lopinavir, (Kaletra), AIDS InfoNet:"WHO SHOULD TAKE KALETRA? Kaletra was approved as an antiviral drug for people with HIV infection. There are no absolute rules about when to start antiviral drugs. You and your doctor should consider your T-cell count, your viral load, any symptoms you are having, and your attitude about taking HIV medications. Fact Sheet 411 has more information about guidelines for the use of antiviral medications. If you take Kaletra with other antiviral drugs, you can reduce your viral load to extremely low levels, and increase your T-cell counts. This should mean staying healthier longer."
http://www.aidsinfonet.org/articles.php?articleID=446

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Lopinavir, (Kaletra) AIDS.ORG:"HOW IS KALETRA TAKEN? Kaletra is taken by mouth as a capsule. Each capsule contains 133 milligrams (mg) of lopinavir and 33 mg of ritonavir. The normal dose is three capsules twice a day. Kaletra should be taken with food. Kaletra is also available in liquid form. The adult dose is 5 milliliters (ml) twice a day. Kaletra is approved for use by children. Their dosage is based on their body weight. Your pharmacist should keep Kaletra refrigerated. When you take it home, you can refrigerate it, or else keep it below 77° F or 25° C and use it within two months."
http://www.aids.org/FactSheets/446-lopinavir.html

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Lopinavir, (Kaletra), HIV and Hepatitis.com:"These data suggest that patients who experience treatment failure on lopinavir might still have a virologic response if treated subsequently with amprenavir- or saquinavir-based regimens. Clinical data from a single patient with a virus that developed 25-fold resistance to lopinavir but retained wild-type sensitivity to amprenavir, and had a good treatment response to that drug with plasma HIV-1 RNA levels that dropped to over 400 copies/mL at week 12. Although these data are encouraging, it is important to note that the patients in this study had all been treated with other protease inhibitors prior to the use of lopinavir. Different patterns of cross-resistance might be observed depending on the specific mutations that emerge during treatment with lopinavir in previously PI-naïve patients."
http://www.hivandhepatitis.com/recent/resistance/021401c.html

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Lopinavir, (Kaletra)Project Inform:"What Does the Research Show? Lopinavir is prepared with a small amount of ritonavir. Thus, ritonavir is present in each lopinavir capsule, significantly boosting and stabilizing lopinavir levels in blood. Early studies suggest that lopinavir is among the most potent anti-HIV drugs studied to date. Lopinavir is being studied as a first line, second line and third line treatment regimen. Early results from these studies show that most people taking lopinavir with nucleoside analogue drugs and in some studies with non-nucleoside reverse transcriptase inhibitors (NNRTIs) have achieved viral load suppression to below 400 copies after 24 weeks. Most of these studies are still ongoing to determine if longer-term suppression of HIV can be sustained. For more information on the specific studies, see Supplemental Information, below."
http://www.projinf.org/fs/lopinavir.html

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Lopinavir, (Kaletra)Test Positive Aware Network:"Tips: Doctors and patients report that this protease inhibitor is very tolerable. Great viral load results out to 72 weeks (significant) in people on their first HIV regimen. Good results also seen in heavily treatment-experienced children and adults, even those with protease inhibitor resistance. However, drug-experienced people also used a non-nuke, which may mean that three classes of HIV drugs are needed for them, and which limits future options. Then again, some people don’t have many options. Expected to successfully control HIV that no longer responds to other meds due to drug resistance, but cross-resistance has already been seen. Can have Norvir’s yucky taste and taste aversion—one guy said his beer tasted like soap. There is hope for once a day dosing."
http://www.tpan.com/publications/drug_guide/drug_Kaletra.html

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Lopinavir, (Kaletra)HIV and Hepatitis.com:"Resistance and Cross-Resistance: Resistance and Cross-Resistance HIV drug resistance can occur when HIV replicates in the presence of antiretroviral drugs. The risk of developing resistance increases greatly when the HIV viral load (RNA) levels are not undetectable despite the taking of antiretroviral drugs. This can occur because of inadequate antiretroviral levels in the blood which may be related to inadequate drug dosing or absorption, increased drug metabolism or not taking the antiretrovirals exactly as directed, that is, poor adherence. HIV resistance to one drug in a class may affect all of the drugs in that class and this is called "cross-resistance". Some mutations that cause resistance to other protease inhibitors may cause Kaletra resistance, so patients who have not taken Kaletra, but have taken other protease inhibitors, may still have HIV with some Kaletra resistance. However, Kaletra's favorable pharmacologic properties and pattern of resistance mutations may enable even heavily PI-experienced patients, whose resident HIV populations may harbor multiple baseline resistance mutations to PIs, to achieve durable suppression of HIV replication."
http://www.hivandhepatitis.com/hiv_and_aids/kaletra_resistance.html

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Lopinavir, (Kaletra)The National AIDS Treatment Information Project (NATIP)":How do I take it? Lopinavir/ritonavir is available in a fixed dose combination capsule (133.3 mg/33.3 mg) and also in an oral solution. The recommended dose is three capsules or 5 ml of oral solution, taken twice a day with a moderate fat meal. Certain drugs should not be taken if you are on lopinavir/ritonavir (Table 1). The doses of lopinavir/ritonavir and some other drugs may need to be adjusted when given together. Because oral contraceptive ("birth control") pills may not be effective with lopinavir/ritonavir, an alternative method should be used to prevent pregnancy. If you are taking lopinavir/ritonavir, always check with your doctor before starting any new medication. You should discuss with your doctor any issues that may interfere with your ability to take this or other antiretroviral medications as prescribed. Taking these medications on time, every day, is a very important factor in determining successful therapy. Frequently missed doses diminish the effectiveness of medications and increase the likelihood that your virus will develop resistance."
http://www.natip.org/lopinavir.html

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